PUMA Protéines
(BCL2 Binding Component 3 (BBC3))
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].
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BBC3
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
Greater than 90 % as determined by SDS-PAGE.
WB, ELISA
1 image
BBC3
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
1 reference
BBC3
Origine: Rat
Hôte: Escherichia coli (E. coli)
Recombinant
> 95 %
WB, SDS, Imm, PC
BBC3
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
WB, SDS, ELISA
custom-made
BBC3
Origine: Souris
Hôte: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
BBC3
Origine: Humain
Hôte: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
BBC3
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
> 90 %
Imm
Inactive
BBC3
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
BBC3
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
~95 %
WB, ELISA, MS
1 image
BBC3
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
WB, SDS, Imm, ELISA
Dernières publications pour nos PUMA Protéines
: "HER2 phosphorylates and destabilizes pro-apoptotic PUMA, leading to antagonized apoptosis in cancer cells." dans: PLoS ONE, Vol. 8, Issue 11, pp. e78836, (2013) (PubMed).
Pseudonymes pour PUMA Protéines
BCL2 binding component 3 (BBC3) ProtéinesBcl-2 binding component 3 (Bbc3) Protéines
BCL2 binding component 3 (Bbc3) Protéines
BCL2 binding component 3 (bbc3) Protéines
BBC3 Protéines
JFY-1 Protéines
JFY1 Protéines
Puma Protéines
PUMA Protéines
PUMA/JFY1 Protéines
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