This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012].
Belichenko, Madani, Rey-Bellet, Pihlgren, Becker, Plassard, Vuillermot, Giriens, Nosheny, Kleschevnikov, Valletta, Bengtsson, Linke, Maloney, Hickman, Reis, Granet, Mlaki, Lopez-Deber, Do, Singhal et al.: "An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. ..." dans: PLoS ONE, Vol. 11, Issue 3, pp. e0152471, (2016) (PubMed).
Segawa, Otsuka, Itou, Suzuki, Karatani, Sakai: "Characterization of the circulating serum amyloid A in bottlenose dolphins." dans: Veterinary immunology and immunopathology, Vol. 152, Issue 3-4, pp. 218-24, (2013) (PubMed).
Pseudonymes pour SAA Protéines
serum amyloid A1 (SAA1) Protéines serum amyloid A (saa) Protéines serum amyloid A protein (LOC476879) Protéines serum amyloid A1 (SAA) Protéines serum amyloid A-3 (SAA3) Protéines HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 (HPS5) Protéines serum amyloid A2 (SAA2) Protéines serum amyloid A 1 (Saa1) Protéines serum amyloid A protein (LOC100270725) Protéines PIG4 Protéines SAA Protéines saa Protéines Saa-1 Protéines SAA1 Protéines SAA2 Protéines Saa2 Protéines TP53I4 Protéines zgc:103580 Protéines