Recombinant Lapin anti-Humain IgA (full length), (Heavy Chain) Anticorps

N° du produit ABIN7879400

Aperçu rapide pour Recombinant Lapin anti-Humain IgA (full length), (Heavy Chain) Anticorps (ABIN7879400)

Antigène: IgA

Type d'anticorp: Recombinant Antibody

Clonalité: Monoclonal

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IGHA-7567R

Isotype: IgG, kappa

Détail du produit

Épitope: full length, Heavy Chain

Reactivité: Humain

Hôte: Lapin

Fonction: Recombinant IgA Antibody / Heavy chain

Purification: Protein A/G affinity

Immunogène: Full-length native purified protein corresponding to Human IgA was used as the immunogen for the recombinant IgA antibody. It is reactive with both IgA1 and IgA2 subclasses of Alpha heavy chain.

Information d'application

Indications d'application: Optimal dilution of the recombinant IgA antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant IgA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détail du antigène

Antigène: IgA

Classe de substances: Antibody

Sujet: This mAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with both IgA1 and IgA2 subclasses of Alpha heavy chain. It reacts with the third constant domain (CH3) of the alpha chain of IgA molecules. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins.IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkin s lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

UniProt: P01876