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SH2B3 Produits

(SH2B Adaptor Protein 3 (SH2B3))

Catégories

This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.[provided by RefSeq, May 2010].

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Catégories SH2B3 en vedette

SH2B3 Anticorps

High quality antibodies with extensive validation data.

SH2B3 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

SH2B3 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, FACS
Validations
  • (2)
N° du produit ABIN6243723
Quantité 50 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (2)
N° du produit ABIN185272
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IF, ICC
Validations
  • (1)
N° du produit ABIN6265048
Quantité 100 μL
Fiche technique Fiche technique

SH2B3 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3077021
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3131375
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7405777
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits SH2B3

Flister, Endres, Rudemiller, Sarkis, Santarriaga, Roy, Lemke, Geurts, Moreno, Ran, Tsaih, De Pons, Carlson, Tan, Fahrenkrug, Lazarova, Lazar, North, LaViolette, Dwinell, Shull, Jacob: "CXM: a new tool for mapping breast cancer risk in the tumor microenvironment." dans: Cancer research, Vol. 74, Issue 22, pp. 6419-29, (2014) (PubMed).

Gery, Cao, Gueller, Xing, Tefferi, Koeffler: "Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F." dans: Journal of leukocyte biology, Vol. 85, Issue 6, pp. 957-65, (2009) (PubMed).

Gery, Gueller, Chumakova, Kawamata, Liu, Koeffler: "Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders." dans: Blood, Vol. 110, Issue 9, pp. 3360-4, (2007) (PubMed).

Fitau, Boulday, Coulon, Quillard, Charreau: "The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways." dans: The Journal of biological chemistry, Vol. 281, Issue 29, pp. 20148-59, (2006) (PubMed).

Tong, Lodish: "Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis." dans: The Journal of experimental medicine, Vol. 200, Issue 5, pp. 569-80, (2004) (PubMed).

Li, He, Schembri-King, Jakes, Hayashi: "Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 10, pp. 5199-206, (2000) (PubMed).

Synonymes et noms alternatifs relatifs à SH2B3

SH2B adaptor protein 3 (SH2B3), SH2B adaptor protein 3 (Sh2b3), AI429800, IDDM20, LNK, Lnk

Protein level used designations for SH2B3

  • lymphocyte adaptor protein
  • SH2B adapter protein 3
  • lymphocyte-specific adapter protein Lnk
  • signal transduction protein Lnk
  • linker of T-cell receptor pathways
  • lymphocyte adapter protein
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