SIGLEC8 Produits
(Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
Catégories
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010].
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Catégories SIGLEC8 en vedette
SIGLEC8 Anticorps
High quality antibodies with extensive validation data.
SIGLEC8 Kits ELISA
Reliable ELISA kits for a wide range of species.
SIGLEC8 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
SIGLEC8 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (3)
- (2)
N° du produit
ABIN544598
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (1)
N° du produit
ABIN565353
Quantité
50 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
N° du produit
ABIN525889
Quantité
100 μg
Fiche technique
Fiche technique
SIGLEC8 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6970205
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6962264
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6959465
Quantité
96 tests
Fiche technique
Fiche technique
SIGLEC8 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
N° du produit
ABIN7275591
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1320000
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN7275601
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits SIGLEC8
: "Expression of Siglec-8 is regulated by interleukin-5, and serum levels of soluble Siglec-8 may predict responsiveness of severe eosinophilic asthma to mepolizumab." dans: Allergology international : official journal of the Japanese Society of Allergology, Vol. 67S, pp. S41-S44, (2019) (PubMed).: "Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis." dans: JCI insight, Vol. 4, Issue 19, (2019) (PubMed).
: "Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement." dans: The Journal of allergy and clinical immunology, Vol. 121, Issue 2, pp. 499-505.e1, (2008) (PubMed).
: "Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies." dans: The Journal of allergy and clinical immunology, Vol. 119, Issue 4, pp. 1005-11, (2007) (PubMed).
: "Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis." dans: Blood, Vol. 101, Issue 12, pp. 5014-20, (2003) (PubMed).
: "Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene." dans: Biochemical and biophysical research communications, Vol. 278, Issue 3, pp. 775-81, (2000) (PubMed).
: "Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily." dans: The Journal of biological chemistry, Vol. 275, Issue 2, pp. 861-6, (2000) (PubMed).
: "Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils." dans: The Journal of allergy and clinical immunology, Vol. 105, Issue 6 Pt 1, pp. 1093-100, (2000) (PubMed).
Synonymes et noms alternatifs relatifs à SIGLEC8
sialic acid binding Ig like lectin 8 (SIGLEC8), sialic acid-binding Ig-like lectin 8 (LOC506364), SAF2, SIGLEC-8, SIGLEC8, SIGLEC8LProtein level used designations for SIGLEC8
- CDw329
- SAF-2
- sialic acid-binding Ig-like lectin 8
- sialoadhesin family member 2
- sialic acid binding Ig-like lectin 8
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