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SIRPA Produits

(Signal-Regulatory Protein alpha (SIRPA))

Catégories

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008].

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Catégories SIRPA en vedette

SIRPA Anticorps

High quality antibodies with extensive validation data.

SIRPA Kits ELISA

Reliable ELISA kits for a wide range of species.

SIRPA Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

SIRPA recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, FACS, ELISA, IHC, ICC, Neut
Validations
  • (1)
  • (4)
N° du produit ABIN5611267
Quantité 0.1 mg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IF
Validations
  • (5)
N° du produit ABIN530824
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application FACS, ELISA, IP, IF
Validations
  • (4)
N° du produit ABIN6961045
Quantité 100 μg
Fiche technique Fiche technique

SIRPA recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6970225
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6962326
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6959481
Quantité 96 tests
Fiche technique Fiche technique

SIRPA recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (8)
N° du produit ABIN7275652
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
N° du produit ABIN7275654
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (4)
N° du produit ABIN7275650
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits SIRPA

Andrejeva, Capoccia, Hiebsch, Donio, Darwech, Puro, Pereira: "Novel SIRPα Antibodies That Induce Single-Agent Phagocytosis of Tumor Cells while Preserving T Cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 206, Issue 4, pp. 712-721, (2021) (PubMed).

Li, Gu, Rao, Lu, Wen, Chen, Wang, Cui, Tang, Xu, Wang, Yu, Ge: "Luteolin promotes macrophage-mediated phagocytosis by inhibiting CD47 pyroglutamation." dans: Translational oncology, Vol. 14, Issue 8, pp. 101129, (2021) (PubMed).

Deuse, Hu, Agbor-Enoh, Jang, Alawi, Saygi, Gravina, Tediashvili, Nguyen, Liu, Valantine, Lanier, Schrepfer: "The SIRPα-CD47 immune checkpoint in NK cells." dans: The Journal of experimental medicine, Vol. 218, Issue 3, (2021) (PubMed).

Wang, Ni, Zhou, He, Gao, Wu, Wu, Wu, Qiu, Zhou, Chen, Pan, Huang, Li, Bian, Yang, Miao, Liu: "Tumor-selective blockade of CD47 signaling with a CD47/PD-L1 bispecific antibody for enhanced anti-tumor activity and limited toxicity." dans: Cancer immunology, immunotherapy : CII, (2020) (PubMed).

Sarute, Ibrahim, Medegan Fagla, Lavanya, Cuevas, Stavrou, Otkiran-Clare, Tyynismaa, Henao-Mejia, Ross: "TRIM2, a novel member of the antiviral family, limits New World arenavirus entry." dans: PLoS biology, Vol. 17, Issue 2, pp. e3000137, (2019) (PubMed).

Yu, Qiu, Long, Yang, Zhang, Xu, Chang, Du, Hou, Yu, Zeng, Wang, Sun: "A novel fully human anti-CD47 antibody as a potential therapy for human neoplasms with good safety." dans: Biochimie, Vol. 151, pp. 54-66, (2018) (PubMed).

Londino, Gulick, Isenberg, Mallampalli: "Cleavage of Signal Regulatory Protein α (SIRPα) Enhances Inflammatory Signaling." dans: The Journal of biological chemistry, Vol. 290, Issue 52, pp. 31113-25, (2015) (PubMed).

Jiang, Zhang, Gao, Zong, Zhou, Liu, Zhang, Bian, Zhu, Fan, Zhang, Li: "Signal regulatory protein-α protects against cardiac hypertrophy via the disruption of toll-like receptor 4 signaling." dans: Hypertension (Dallas, Tex. : 1979), Vol. 63, Issue 1, pp. 96-104, (2013) (PubMed).

Price, Hope: "Enhanced secretion of interferon-gamma by bovine gammadelta T cells induced by coculture with Mycobacterium bovis-infected dendritic cells: evidence for reciprocal activating signals." dans: Immunology, Vol. 126, Issue 2, pp. 201-8, (2009) (PubMed).

Waters, Palmer, Nonnecke, Thacker, Estes, Larsen, Jacobs, Andersen, McNair, Minion, Lyashchenko, Hewinson, Vordermeier, Sacco: "Signal regulatory protein alpha (SIRPalpha) cells in the adaptive response to ESAT-6/CFP-10 protein of tuberculous mycobacteria." dans: PLoS ONE, Vol. 4, Issue 7, pp. e6414, (2009) (PubMed).

Synonymes et noms alternatifs relatifs à SIRPA

signal regulatory protein alpha (SIRPA), myeloperoxidase (MPO), signal-regulatory protein alpha (SIRPA), tyrosine-protein phosphatase non-receptor type substrate 1 (LOC458039), tyrosine-protein phosphatase non-receptor type substrate 1 (LOC100400378), tyrosine-protein phosphatase non-receptor type substrate 1 (LOC100590224), signal-regulatory protein alpha (Sirpa), AI835480, BIT, Bit, CD172A, CD172a, MFR, MYD-1, P84, PTPNS1, Ptpns1, SHP-1, SHPS-1, SHPS1, SIRP, SIRP-A1, SIRP-B1, SIRPA, swc3

Protein level used designations for SIRPA

  • CD172 antigen-like family member A
  • brain-immunoglobulin-like molecule with tyrosine-based activation motifs
  • inhibitory receptor SHPS-1
  • macrophage fusion receptor
  • myd-1 antigen
  • tyrosine phosphatase SHP substrate 1
  • tyrosine-protein phosphatase non-receptor type substrate 1
  • MyD-1 antigen
  • SHP substrate 1
  • SHPS-1
  • protein tyrosine phosphatase, non-receptor type substrate 1
  • signal-regulatory protein alpha-1
  • sirp-alpha-1
  • signal-regulatory protein alpha
  • signal regulatory protein alpha
  • tyrosine-protein phosphatase non-receptor type substrate 1-like
  • brain Ig-like molecule with tyrosine-based activation motifs
  • brain immunological-like with tyrosine-based motifs
  • mSIRP-alpha1
  • myD-1 antigen
  • Brain immunoglobulin like protein with tyrosine - based activation motifs
  • Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1)
  • Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1)
  • macrophage membrane protein MFP150
  • swine workshop cluster 3 antigen
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