SLUG Produits
(Snail Family Zinc Finger 2 (SNAI2))
Catégories
Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box- containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). {ECO:0000250}.
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Catégories SLUG en vedette
SLUG Anticorps
High quality antibodies with extensive validation data.
SLUG Kits ELISA
Reliable ELISA kits for a wide range of species.
SLUG Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
SLUG recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (8)
N° du produit
ABIN5542256
Quantité
0.1 mg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (7)
N° du produit
ABIN520276
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (5)
N° du produit
ABIN520274
Quantité
100 μg
Fiche technique
Fiche technique
SLUG recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6970264
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Cow
Analytical Method
Validations
N° du produit
ABIN1168733
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6200993
Quantité
96 tests
Fiche technique
Fiche technique
SLUG recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1320743
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1320742
Quantité
25 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
N° du produit
ABIN3095594
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits SLUG
: "CO suppresses prostate cancer cell growth by directly targeting LKB1/AMPK/mTOR pathway in vitro and in vivo." dans: Urologic oncology, Vol. 36, Issue 6, pp. 312.e1-312.e8, (2018) (PubMed).: "Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling." dans: Cell death & disease, Vol. 9, Issue 8, pp. 802, (2018) (PubMed).
: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." dans: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).
: "EGCG regulates the cross-talk between JWA and topoisomerase IIα in non-small-cell lung cancer (NSCLC) cells." dans: Scientific reports, Vol. 5, pp. 11009, (2016) (PubMed).
: "Claudin-3 is required for modulation of paracellular permeability by TNF-α through ERK1/2/slug signaling axis in submandibular gland." dans: Cellular signalling, Vol. 27, Issue 10, pp. 1915-27, (2016) (PubMed).
: "Silencing of Antichondrogenic MicroRNA-221 in Human Mesenchymal Stem Cells Promotes Cartilage Repair In Vivo." dans: Stem cells (Dayton, Ohio), Vol. 34, Issue 7, pp. 1801-11, (2016) (PubMed).
: "Slug transcription factor and nuclear Lamin B1 are upregulated in osteoarthritic chondrocytes." dans: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 23, Issue 7, pp. 1226-30, (2015) (PubMed).
: "Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells." dans: Oncogene, Vol. 34, Issue 5, pp. 546-57, (2015) (PubMed).
: "SNAILs promote G1 phase in selected cancer cells." dans: International journal of oncology, Vol. 47, Issue 5, pp. 1863-73, (2015) (PubMed).
: "miR-33a suppresses the nuclear translocation of ?-catenin to enhance gemcitabine sensitivity in human pancreatic cancer cells." dans: Tumour biology, (2015) (PubMed).
Synonymes et noms alternatifs relatifs à SLUG
snail family transcriptional repressor 2 (Snai2), snail family zinc finger 2 (Snai2), Slug, Slugh, Snail2Protein level used designations for SLUG
- Neural crest transcription factor Slug
- Protein snail homolog 2
- Slug, chicken homolog
- neural crest transcription factor Slug
- protein snail homolog 2
- snail family zinc finger 2
- snail homolog 2
- zinc finger protein SNAI2
- slug, chicken homolog
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