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SMAD7 Produits

(SMAD, Mothers Against DPP Homolog 7 (SMAD7))
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

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Catégories SMAD7 en vedette

SMAD7 Anticorps

High quality antibodies with extensive validation data.

SMAD7 Kits ELISA

Reliable ELISA kits for a wide range of species.

SMAD7 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

SMAD7 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), FACS
Validations
  • (3)
  • (5)
N° du produit ABIN670206
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IF
Validations
  • (5)
N° du produit ABIN7270356
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (2)
  • (4)
N° du produit ABIN517666
Quantité 100 μg
Fiche technique Fiche technique

SMAD7 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6959527
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6970256
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6970255
Quantité 96 tests
Fiche technique Fiche technique

SMAD7 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1320614
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3095441
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3131491
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits SMAD7

Tang, Reissig, Glasmacher, Regen, Wanke, Nikolaev, Gerlach, Popp, Karram, Fantini, Schattenberg, Galle, Neurath, Weigmann, Kurschus, Hövelmeyer, Waisman: "Alternative Splice Forms of CYLD Mediate Ubiquitination of SMAD7 to Prevent TGFB Signaling and Promote Colitis." dans: Gastroenterology, Vol. 156, Issue 3, pp. 692-707.e7, (2019) (PubMed).

Yang, Ding, Xu, Chen, Ding: "MicroRNA-15a inhibition protects against hypoxia/reoxygenation-induced apoptosis of cardiomyocytes by targeting mothers against decapentaplegic homolog 7." dans: Molecular medicine reports, Vol. 15, Issue 6, pp. 3699-3705, (2017) (PubMed).

Yang, Luo, Zhu, Zhou, Wang, Xue, Zhang, Cai, Chen, Ma, Chen, Wang, Luo, Liu, Zhao: "Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo." dans: Frontiers in pharmacology, Vol. 8, pp. 929, (2017) (PubMed).

Zhuang, Yang, Ma, Han, Wang, Zhao, Wu, Qu: "MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST." dans: Cell death & disease, Vol. 7, pp. e2203, (2016) (PubMed).

Aparecida-Silva, Borges, Kessler, Dias, Moreira, Kalil, Gutierrez: "Transforming growth factor-β1 SMAD effectors and medial cell number in ascending aorta diseases." dans: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, Vol. 25, Issue 3, pp. 240-6, (2016) (PubMed).

Shang, Liu, Liu, Zhang, Mu, Zhu, Liang, Zhai, Ding, Li, Wen: "Acetyl-11-Keto-β-Boswellic Acid Attenuates Prooxidant and Profibrotic Mechanisms Involving Transforming Growth Factor-β1, and Improves Vascular Remodeling in Spontaneously Hypertensive Rats." dans: Scientific reports, Vol. 6, pp. 39809, (2016) (PubMed).

Piotrowski, Kiszałkiewicz, Górski, Antczak, Górski, Pastuszak-Lewandoska, Migdalska-Sęk, Domańska-Senderowska, Nawrot, Czarnecka, Kurmanowska, Brzeziańska-Lasota: "Immunoexpression of TGF-β/Smad and VEGF-A proteins in serum and BAL fluid of sarcoidosis patients." dans: BMC immunology, Vol. 16, pp. 58, (2015) (PubMed).

Liu, Shi, Yang, Zhao, Du, Zou, Yu: "Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy." dans: Synapse (New York, N.Y.), Vol. 68, Issue 6, pp. 275-82, (2014) (PubMed).

Gao, Aqie, Zhu, Chen, Xu, Jiang, Xu: "MG132 ameliorates kidney lesions by inhibiting the degradation of Smad7 in streptozotocin-induced diabetic nephropathy." dans: Journal of diabetes research, Vol. 2014, pp. 918396, (2014) (PubMed).

Kayalar, Oztay: "Retinoic acid induced repair in the lung of adult hyperoxic mice, reducing transforming growth factor-β1 (TGF-β1) mediated abnormal alterations." dans: Acta histochemica, Vol. 116, Issue 5, pp. 810-9, (2014) (PubMed).

Synonymes et noms alternatifs relatifs à SMAD7

SMAD family member 7 (SMAD7), SMAD family member 7 (Smad7), SMAD family member 7 L homeolog (smad7.L), SMAD family member 7 (smad7), CRCS3, MADH7, Madh7, madh7, MADH8, Smad7a, Smad10, wu:fj60c10, xsmad7

Protein level used designations for SMAD7

  • MAD (mothers against decapentaplegic, Drosophila) homolog 7
  • MAD homolog 8
  • Mothers against decapentaplegic, drosophila, homolog of, 7
  • SMAD, mothers against DPP homolog 7
  • hSMAD7
  • mothers against DPP homolog 8
  • mothers against decapentaplegic homolog 7
  • SMAD family member 7
  • MAD homolog 7
  • SMAD 7
  • madh8
  • mothers against DPP homolog 7
  • mothers against decapentaplegic homolog 8
  • mothers against DPP 7
  • mothers against decapentaplegic-like protein 7
  • MAD, mothers against decapentaplegic homolog 7
  • fj60c10
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