SNRPN Produits
(Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))
Catégories
The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. [provided by RefSeq, Jul 2008].
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Catégories SNRPN en vedette
SNRPN Anticorps
High quality antibodies with extensive validation data.
SNRPN Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
SNRPN recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Dog, Human, Mouse, Rat
Application
WB, IF, BI, IHC (f)
Validations
- (6)
- (6)
N° du produit
ABIN968086
Quantité
150 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), ICC
Validations
- (5)
N° du produit
ABIN3032638
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Dog, Human, Mouse, Rat
Application
WB, IF, BI, IHC (f)
Validations
- (5)
- (3)
N° du produit
ABIN968085
Quantité
50 μg
Fiche technique
Fiche technique
SNRPN recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6233363
Quantité
96 tests
Fiche technique
Fiche technique
SNRPN recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7125138
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7125137
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1320836
Quantité
25 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits SNRPN
: "A new biomarker candidate for spinal muscular atrophy: Identification of a peripheral blood cell population capable of monitoring the level of survival motor neuron protein." dans: PLoS ONE, Vol. 13, Issue 8, pp. e0201764, (2019) (PubMed).: "Urethral proteomic analysis in ovariectomized mice administered 17β-oestradiol replacement therapy." dans: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, pp. 1-9, (2017) (PubMed).
: "Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22." dans: Disease models & mechanisms, Vol. 10, Issue 3, pp. 215-224, (2017) (PubMed).
: "Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish." dans: Scientific reports, Vol. 6, pp. 27470, (2016) (PubMed).
: "Effect of small nuclear ribonucleoprotein-associated polypeptide N on the proliferation of medulloblastoma cells." dans: Molecular medicine reports, Vol. 11, Issue 5, pp. 3337-43, (2015) (PubMed).
: "Systematic identification of novel SLE related autoantibodies responsible for type I IFN production in human plasmacytoid dendritic cells." dans: Cellular immunology, Vol. 284, Issue 1-2, pp. 119-28, (2013) (PubMed).
: "Utility of survival motor neuron ELISA for spinal muscular atrophy clinical and preclinical analyses." dans: PLoS ONE, Vol. 6, Issue 8, pp. e24269, (2011) (PubMed).
: "Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesis." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 6, pp. 1959-64, (2007) (PubMed).
: "SMN, the product of the spinal muscular atrophy-determining gene, is expressed widely but selectively in the developing human forebrain." dans: The Journal of comparative neurology, Vol. 497, Issue 5, pp. 808-16, (2006) (PubMed).
: "snRNAs contain specific SMN-binding domains that are essential for snRNP assembly." dans: Molecular and cellular biology, Vol. 24, Issue 7, pp. 2747-56, (2004) (PubMed).
Synonymes et noms alternatifs relatifs à SNRPN
small nuclear ribonucleoprotein polypeptide-like (SNRPL), small nuclear ribonucleoprotein polypeptides B and B1 (snrpb), small nuclear ribonucleoprotein polypeptide N (SNRPN), small nuclear ribonucleoprotein N (Snrpn), small nuclear ribonucleoprotein polypeptide N (Snrpn), small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51 (snrpn), SNRPN upstream reading frame (SNURF), Small nuclear ribonucleoprotein-associated protein N (SNRPN), 2410045I01Rik, FE 294, FE294, FE 294 psi, FE294 psi, HCERN3, Peg4, PWCR, Pwcr1, QflA-11237, QtrA-10022, RT-LI, SM-D, sm-N, Sm-N, SMN, SmN, SNRB', SNRNP-N, snRNP-N, SNRPB', Snrpn, SNRPN, SNURF, SNURF-SNRPN, zgc:77315Protein level used designations for SNRPN
- sm protein B'
- sm-B'
- smB'
- small nuclear ribonucleoprotein B
- small nuclear ribonucleoprotein B'
- small nuclear ribonucleoprotein polypeptide B/B'
- small nuclear ribonucleoprotein-associated protein B'
- snRNP-B'
- snRNP-associated protein
- SM protein N
- sm protein D
- small nuclear ribonucleoprotein-associated protein N
- tissue-specific splicing protein
- sm protein N
- sm-D
- sm-N
- snRNP-N
- tissue-specific-splicing protein
- FE294 gene for snRNP-associated polypeptide N
- FE294 psi pseudogene
- smN
- small nuclear ribonucleoparticle-associated protein (snRNP) mRNA clone Sm51
- small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51
- small nuclear ribonucleoprotein N
- SNRPN upstream reading frame
- SNRPN upstream reading frame protein
- small nuclear ribonucleoprotein polypeptide N
- SNRPN upstream reading frame product
- Sm protein N
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