(Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
signal transducer and activator of transcription 1 (STAT1) Protéines signal transducer and activator of transcription 1 (Stat1) Protéines signal transducer and activator of transcription 1 L homeolog (stat1.L) Protéines signal transducer and activator of transcription 1, 91kDa (STAT1) Protéines signal transducer and activator of transcription 4 (stat4) Protéines signal transducer and activator of transcription 1a (stat1a) Protéines 2010005J02Rik Protéines AA408197 Protéines CANDF7 Protéines DD6G4-4 Protéines dZ182H3.3 Protéines ISGF-3 Protéines si:by51f19.1 Protéines si:by134g18.2 Protéines si:dz73o4.2 Protéines si:dz182h3.3 Protéines si:dz199m19.1 Protéines STAT Protéines STAT1 Protéines stat1 Protéines STAT4 Protéines STAT91 Protéines XStat1 Protéines