STAT1 Protéine

N° du produit ABIN7319272

Protéine Recombinant STAT1 exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour STAT1 Protéine (ABIN7319272)

Antigène: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 68 % as determined by reducing SDS-PAGE.

Détail du produit

Fonction: Recombinant Human STAT1 Protein

Séquence: Met 1-Val712

Attributs du produit: Recombinant Human Signal Transducer and Activator of Transcription 1 is produced by our E.coli expression system and the target gene encoding Met1-Val712 is expressed.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 0.02 % Tween 80, 5 % Sucrose, 4 % Mannitol, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Autre désignation: STAT1

Sujet: CANDF7,IMD31A,IMD31B,IMD31C,ISGF-3,STAT1,STAT91,Signal Transducer and Activator of Transcription 1-Alpha/Beta,Transcription Factor ISGF-3 Components p91/p84,Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellular responses to interferons. Defects in STAT1 are the cause of STAT1 deficiency complete and familial candidiasis type 7.

Poids moléculaire:

Calculated MW: 83.3 kDa

Observed MW: 85 kDa

ID gène: 6772

UniProt: P42224

Pathways: Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events