Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

TAB1 Produits

(TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))

Catégories

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

antibodies-online.com est synonyme de produits de recherche de haute qualité. Cherchez, trouvez et commandez des outils avec des données de validation étendues, des images, des références. Notre service clientèle scientifique est toujours à votre disposition si vous avez des questions sur la sélection ou l'application de nos produits.

Catégories TAB1 en vedette

TAB1 Anticorps

High quality antibodies with extensive validation data.

TAB1 Kits ELISA

Reliable ELISA kits for a wide range of species.

TAB1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

TAB1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IF, PLA
Validations
  • (6)
N° du produit ABIN564552
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (4)
N° du produit ABIN7171965
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (3)
N° du produit ABIN523851
Quantité 200 μL
Fiche technique Fiche technique

TAB1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6970603
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6229502
Quantité 96 tests
Fiche technique Fiche technique

TAB1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7125344
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1310231
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1310229
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits TAB1

Hussain, Zhao, Shah, Wang, Yue, Liao, Sabir, Yang, Zhou et al.: "MicroRNA 27a-3p Regulates Antimicrobial Responses of Murine Macrophages Infected by Mycobacterium avium subspecies paratuberculosis by Targeting Interleukin-10 and TGF-β-Activated Protein Kinase 1 ..." dans: Frontiers in immunology, Vol. 8, pp. 1915, (2017) (PubMed).

Shen, Gloster, Yuzwa, Vocadlo: "Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates." dans: The Journal of biological chemistry, Vol. 287, Issue 19, pp. 15395-408, (2012) (PubMed).

Sun, Yoshizuka, New, Moser, Li, Liao, Xie, Chen, Deng, Yamout, Dong, Frangou, Yates, Wright, Han: "PRAK is essential for ras-induced senescence and tumor suppression." dans: Cell, Vol. 128, Issue 2, pp. 295-308, (2007) (PubMed).

Zhou, Zheng, Chen, Xie, Kolatkar, Zarubin, Ye, Akella, Lin, Goldsmith, Han: "Determinants that control the specific interactions between TAB1 and p38alpha." dans: Molecular and cellular biology, Vol. 26, Issue 10, pp. 3824-34, (2006) (PubMed).

Conner, Kular, Peggie, Shepherd, Schüttelkopf, Cohen, Van Aalten: "TAK1-binding protein 1 is a pseudophosphatase." dans: The Biochemical journal, Vol. 399, Issue 3, pp. 427-34, (2006) (PubMed).

Singhirunnusorn, Suzuki, Kawasaki, Saiki, Sakurai et al.: "Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex ..." dans: The Journal of biological chemistry, Vol. 280, Issue 8, pp. 7359-68, (2005) (PubMed).

Schimmer: "Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice." dans: Cancer research, Vol. 64, Issue 20, pp. 7183-90, (2004) (PubMed).

Akira, Takeda: "Toll-like receptor signalling." dans: Nature reviews. Immunology, Vol. 4, Issue 7, pp. 499-511, (2004) (PubMed).

Li, Yang, Ashwell: "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2." dans: Nature, Vol. 416, Issue 6878, pp. 345-7, (2002) (PubMed).

Jiang, Ninomiya-Tsuji, Qian, Matsumoto, Li: "Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol." dans: Molecular and cellular biology, Vol. 22, Issue 20, pp. 7158-67, (2002) (PubMed).

Synonymes et noms alternatifs relatifs à TAB1

TGF-beta activated kinase 1 (MAP3K7) binding protein 1 (TAB1), TGF-beta activated kinase 1/MAP3K7 binding protein 1 (Tab1), 3'-Tab1, 2310012M03Rik, b2b449Clo, MAP3K7IP1, Map3k7ip1

Protein level used designations for TAB1

  • TAK1-binding protein 1
  • TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
  • mitogen-activated protein kinase kinase kinase 7-interacting protein 1
  • transforming growth factor beta-activated kinase-binding protein 1
  • TGF-beta-activated kinase 1-binding protein 1
  • Tak1-binding protein 1
  • beta activated kinase-1 binding protein-1
  • mitogen activated protein kinase kinase kinase 7 interacting protein 1
  • mitogen-activated protein kinase kinase kinase 7 interacting protein 1
Vous êtes ici:
Support technique