TNFSF11 (Denosumab Biosimilar) Anticorps
(TNFSF11 (Denosumab Biosimilar))
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008].
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TNFSF11 (Denosumab Biosimilar) recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
FACS, in vivo
Validations
N° du produit
ABIN7200656
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Human
Application
FACS
Validations
N° du produit
ABIN7093075
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
Validations
N° du produit
ABIN7487780
Quantité
100 μg
Fiche technique
Fiche technique
Synonymes et noms alternatifs relatifs à TNFSF11 (Denosumab Biosimilar)
TNF superfamily member 11 (TNFSF11), CD254, hRANKL2, ODF, OPGL, OPTB2, RANKL, sOdf, TRANCEProtein level used designations for TNFSF11 (Denosumab Biosimilar)
- TNF-related activation-induced cytokine
- osteoclast differentiation factor
- osteoprotegerin ligand
- receptor activator of nuclear factor kappa B ligand
- receptor activator of nuclear factor kappa-B ligand
- tumor necrosis factor ligand superfamily member 11
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