USP8 Produits
(Ubiquitin Specific Peptidase 8 (USP8))
Catégories
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.
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Catégories USP8 en vedette
USP8 Anticorps
High quality antibodies with extensive validation data.
USP8 Kits ELISA
Reliable ELISA kits for a wide range of species.
USP8 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
USP8 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF, IHC (p), IP, ICC
Validations
- (4)
N° du produit
ABIN2855692
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (2)
N° du produit
ABIN7174360
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
N° du produit
ABIN388891
Quantité
400 μL
Fiche technique
Fiche technique
USP8 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6960352
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
N° du produit
ABIN1117711
Quantité
96 tests
Fiche technique
Fiche technique
USP8 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7125599
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
N° du produit
ABIN3096238
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7398275
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits USP8
: "Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer. ..." dans: Nature communications, Vol. 7, pp. 11971, (2016) (PubMed).: "Mutations in the deubiquitinase gene USP8 cause Cushing's disease." dans: Nature genetics, Vol. 47, Issue 1, pp. 31-8, (2014) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
: "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease." dans: Oncogene, Vol. 20, Issue 29, pp. 3869-79, (2001) (PubMed).
Synonymes et noms alternatifs relatifs à USP8
ubiquitin carboxyl-terminal hydrolase 8 (LOC9310109), ubiquitin carboxyl-terminal hydrolase 8 (MGYG_00369), ubiquitin specific peptidase 8 (USP8), ubiquitin specific peptidase 8 (Usp8), AI574262, AW557536, HumORF8, mKIAA0055, UBPY, UbpyProtein level used designations for USP8
- ubiquitin carboxyl-terminal hydrolase 8
- ubiquitin-specific-processing protease 8
- ubiquitin specific peptidase 8
- ubiquitin carboxyl-terminal hydrolase 8-like
- deubiquitinating enzyme 8
- hUBPy
- ubiquitin isopeptidase Y
- ubiquitin specific protease 8
- ubiquitin thioesterase 8
- ubiquitin thiolesterase 8
- putative deubiquitinating enzyme
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