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WFDC2 Produits

(WAP Four-Disulfide Core Domain 2 (WFDC2))
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008].

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Catégories WFDC2 en vedette

WFDC2 Anticorps

High quality antibodies with extensive validation data.

WFDC2 Kits ELISA

Reliable ELISA kits for a wide range of species.

WFDC2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

WFDC2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse, Rat
Application ELISA, WB, IHC (p)
Validations
  • (6)
N° du produit ABIN5519074
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application ELISA, WB, IHC, IF
Validations
  • (4)
N° du produit ABIN7175671
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IHC (p)
Validations
  • (4)
N° du produit ABIN1491389
Quantité 100 μL
Fiche technique Fiche technique

WFDC2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6962650
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6960523
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6976023
Quantité 96 tests
Fiche technique Fiche technique

WFDC2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Dog
Source HEK-293 Cells
Validations
  • (2)
N° du produit ABIN7274791
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
N° du produit ABIN1325310
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7125722
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits WFDC2

Yang, Lu, Guo, Fellman, Ning, Lu, Menon, Kobayashi, Hanash, Celestino, Skates, Bast: "Human epididymis protein 4 antigen-autoantibody complexes complement cancer antigen 125 for detecting early-stage ovarian cancer." dans: Cancer, (2019) (PubMed).

Dong, Liu, Li: "Value of HE4 Combined with Cancer Antigen 125 in the Diagnosis of Endometrial Cancer." dans: Pakistan journal of medical sciences, Vol. 33, Issue 4, pp. 1013-1017, (2017) (PubMed).

Zhou, Lv, Shao, Xu, Luo, Zhang, Hu, Zhang, Luo, Fang, Wang, Duan, Huang: "Detection of Human Epididymis Protein 4 (HE4) in Human Serum Samples Using a Specific Monoclonal Antibody-Based Sandwich Enzyme-Linked Immunosorbent Assay (ELISA)." dans: Journal of clinical laboratory analysis, Vol. 30, Issue 5, pp. 581-9, (2017) (PubMed).

Eaton, Shallcross, Mael, Mears, Minkoff, Scoville, Whelan: "Selection of DNA aptamers for ovarian cancer biomarker HE4 using CE-SELEX and high-throughput sequencing." dans: Analytical and bioanalytical chemistry, (2015) (PubMed).

Moore, Hill, Horan, Yano, Kim, MacLaughlan, Lambert-Messerlian, Tseng, Padbury, Miller, Lange, Singh: "HE4 (WFDC2) gene overexpression promotes ovarian tumor growth." dans: Scientific reports, Vol. 4, pp. 3574, (2014) (PubMed).

LeBleu, Teng, OConnell, Charytan, Müller, Müller, Sugimoto, Kalluri: "Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis." dans: Nature medicine, Vol. 19, Issue 2, pp. 227-31, (2013) (PubMed).

Yuan, Duan, Yang, Luo, Xi: "Detection of serum human epididymis secretory protein 4 in patients with ovarian cancer using a label-free biosensor based on localized surface plasmon resonance." dans: International journal of nanomedicine, Vol. 7, pp. 2921-8, (2012) (PubMed).

Huhtinen, Suvitie, Hiissa, Junnila, Huvila, Kujari, Setälä, Härkki, Jalkanen, Fraser, Mäkinen, Auranen, Poutanen, Perheentupa: "Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts." dans: British journal of cancer, Vol. 100, Issue 8, pp. 1315-9, (2009) (PubMed).

Hellström, Raycraft, Hayden-Ledbetter, Ledbetter, Schummer, McIntosh, Drescher, Urban, Hellström: "The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma." dans: Cancer research, Vol. 63, Issue 13, pp. 3695-700, (2003) (PubMed).

Kirchhoff, Habben, Ivell, Krull: "A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors." dans: Biology of reproduction, Vol. 45, Issue 2, pp. 350-7, (1992) (PubMed).

Synonymes et noms alternatifs relatifs à WFDC2

WAP four-disulfide core domain 2 (WFDC2), WAP four-disulfide core domain 2 (wfdc2), WAP four-disulfide core domain 2 (Wfdc2), 1600023A02Rik, BE-20, CE4, dJ461P17.6, EDDM4, HE4, re4, si:ch211-153a8.3, WAP5, WFDC2, WFDC3

Protein level used designations for WFDC2

  • WAP four-disulfide core domain 2
  • WAP four-disulfide core domain 3
  • WAP four-disulfide core domain protein 2
  • WAP domain containing protein HE4-V4
  • epididymal protein 4
  • epididymal secretory protein E4
  • epididymis-specific, whey-acidic protein type, four-disulfide core
  • major epididymis-specific protein E4
  • putative protease inhibitor WAP5
  • WAP domain-containing protein HE4
  • epididymal secretory protein 4
  • epididymal protein BE-20
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