ERBB3 anticorps (C-Term, Isoform 1)
Aperçu rapide pour ERBB3 anticorps (C-Term, Isoform 1) (ABIN374599)
Antigène
Voir toutes ERBB3 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- C-Term, Isoform 1
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Specificité
- This antibody is expected to recognise isoform 1 of ERBB3 only.
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Réactivité croisée (Details)
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Species reactivity (expected):Mouse, Rat, Canine, Porcine, Bovine.
Species reactivity (tested):Human. -
Purification
- Affinity chromatography
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Immunogène
- Peptide with sequence C-HSRLFPKANAQRT, from the C Terminus of the protein sequence
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anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 707-964) antibody
ERBB3 Reactivité: Souris WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 24-55), (N-Term) antibodyERBB3 Reactivité: Humain, Souris WB, FACS, IHC (p) Hôte: Lapin Polyclonal RB01467 unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (C-Term) antibodyERBB3 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 1-130) antibodyERBB3 Reactivité: Humain WB, ELISA, IHC (p) Hôte: Souris Monoclonal 2E9 unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pTyr1289) antibodyERBB3 Reactivité: Humain, Souris, Rat WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) antibodyERBB3 Reactivité: Humain WB, IP, IHC (fro), IHC (f) Hôte: Souris Monoclonal RTJ-1 unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 24-55) antibodyERBB3 Reactivité: Humain, Souris WB, IHC, ELISA, FACS Hôte: Lapin Polyclonal unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (C-Term) antibodyVerified ERBB3 Reactivité: Humain IHC, ELISA, IF, FACS Hôte: Chèvre Polyclonal unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 21-332) antibodyERBB3 Reactivité: Humain IHC, ELISA, IHC (p) Hôte: Souris Monoclonal 3F12 unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 1-131) antibodyERBB3 Reactivité: Humain WB, IHC, ELISA, IHC (p) Hôte: Souris Monoclonal 2E9 unconjugated
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Indications d'application
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Peptide ELISA: 1/32000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Concentration
- 0,5 mg/mL
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Buffer
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freezing and thawing.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
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Autre désignation
- ERBB3 / HER3
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Sujet
- The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.Synonyms: ERBB-3, HER-3, Proto-oncogene-like protein c-ErbB-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, c-erbB-3
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ID gène
- 2065
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NCBI Accession
- NP_001005915
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UniProt
- P21860
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Pathways
- Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Antigène
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