ERBB3 anticorps
Aperçu rapide pour ERBB3 anticorps (ABIN645836)
Antigène
Voir toutes ERBB3 AnticorpsReactivité
Hôte
Conjugué
Application
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Specificité
- The ErbB3 goat antibody detects protein derived from human, Jurkat cell lysate at various concentrations.
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Réactivité croisée
- Souris, Rat (Rattus)
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Attributs du produit
- Goat Anti-ERBB3 / HER3
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Immunogène
- Peptide with sequence -HSRLFPKANAQRT, from the C-terminus of the protein sequence according to NP_001973.2. was used as immunogen.
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Isotype
- IgG
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anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 707-964) antibody
ERBB3 Reactivité: Souris WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 24-55), (N-Term) antibodyERBB3 Reactivité: Humain, Souris WB, FACS, IHC (p) Hôte: Lapin Polyclonal RB01467 unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (C-Term) antibodyERBB3 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 1-130) antibodyERBB3 Reactivité: Humain WB, ELISA, IHC (p) Hôte: Souris Monoclonal 2E9 unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pTyr1289) antibodyERBB3 Reactivité: Humain, Souris, Rat WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) antibodyERBB3 Reactivité: Humain WB, IP, IHC (fro), IHC (f) Hôte: Souris Monoclonal RTJ-1 unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 24-55) antibodyERBB3 Reactivité: Humain, Souris WB, IHC, ELISA, FACS Hôte: Lapin Polyclonal unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (C-Term) antibodyVerified ERBB3 Reactivité: Humain IHC, ELISA, IF, FACS Hôte: Chèvre Polyclonal unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 21-332) antibodyERBB3 Reactivité: Humain IHC, ELISA, IHC (p) Hôte: Souris Monoclonal 3F12 unconjugated
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 1-131) antibodyERBB3 Reactivité: Humain WB, IHC, ELISA, IHC (p) Hôte: Souris Monoclonal 2E9 unconjugated
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Restrictions
- For Research Use only
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Reconstitution
- Supplied as 100 µg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.
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Stock
- -20 °C
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- ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
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Autre désignation
- ERBB3 / HER3
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Sujet
- The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is detected at 180 kDa by SDS-PAGE and is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form of 85 kDa which negatively regulates heregulin-stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.
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NCBI Accession
- NP_001973
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Pathways
- Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Antigène
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