LCP2 anticorps (AA 216-434)
Aperçu rapide pour LCP2 anticorps (AA 216-434) (ABIN94466)
Antigène
Voir toutes LCP2 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- AA 216-434
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Fonction
- Anti-SLP76 Purified
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Réactivité croisée (Details)
- Mouse, Human, Porcine
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Attributs du produit
- The monoclonal antibody reacts with SLP76, a 76 kDa cytosolic adaptor protein that is involved in signaling of various hematopoietic cells, such as T cells, mast cells or neutrophils, in B cells, however, it is replaced by SLP65.
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Purification
- Purified by protein-A affinity chromatography.
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Pureté
- > 95 % (by SDS-PAGE)
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Immunogène
- Bacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag
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Isotype
- IgG2b
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anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 202-463) antibody
LCP2 Reactivité: Souris WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (N-Term) antibodyVerified LCP2 Reactivité: Humain WB, ELISA Hôte: Chèvre Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 284-533) antibodyLCP2 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) antibodyLCP2 Reactivité: Humain WB, FACS Hôte: Lapin Monoclonal 25GB1910 unconjugated Recombinant Antibody
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 216-434) antibodyLCP2 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 94-143), (pTyr128) antibodyLCP2 Reactivité: Humain, Souris, Rat WB, IHC, ELISA Hôte: Lapin Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 46-80) antibodyLCP2 Reactivité: Humain WB Hôte: Lapin Polyclonal RB56244 unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 303-337) antibodyLCP2 Reactivité: Humain WB Hôte: Lapin Polyclonal RB56245 unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 1-533) antibodyLCP2 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 1-533) antibodyLCP2 Reactivité: Humain WB Hôte: Souris Polyclonal unconjugated
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Indications d'application
- Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/mL, positive tissue: thymus
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Do not freeze
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Stock
- 4 °C
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Stockage commentaire
- Store at 2-8°C. Do not freeze.
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- LCP2 (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))
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Autre désignation
- SLP76
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Sujet
- Lymphocyte cytosolic protein 2,SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets, B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.,SLP-76, LCP2
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ID gène
- 3937
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UniProt
- Q13094
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Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
Antigène
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