TNFRSF10B anticorps (Extracellular Domain)
Aperçu rapide pour TNFRSF10B anticorps (Extracellular Domain) (ABIN238401)
Antigène
Voir toutes TNFRSF10B AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- Extracellular Domain
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Specificité
- The antibody DR5-01-1 recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L).
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Réactivité croisée (Details)
- Species reactivity (tested):Human.
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Attributs du produit
- Synonyms: TNFRSF10B, DR5, KILLER, TRICK2, ZTNFR9, Death receptor 5, TRAIL receptor 2, TRAIL-R2,Tumor necrosis factor receptor superfamily member 10B, TNF-related apoptosis-inducingligand receptor 2
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Purification
- Protein-A Affinity Chromatography.
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Immunogène
- Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.
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Isotype
- IgG1
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anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 234-435) antibody
TNFRSF10B Reactivité: Humain WB, IHC, ICC, IF Hôte: Lapin Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 233-440) antibodyTNFRSF10B Reactivité: Humain, Souris, Rat WB, FACS, IHC Hôte: Lapin Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) antibodyTNFRSF10B Reactivité: Humain WB, IHC, IF Hôte: Lapin Monoclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 1-440) antibodyTNFRSF10B Reactivité: Humain WB, IP Hôte: Lapin Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 71-170) antibodyTNFRSF10B Reactivité: Humain WB, ELISA, IP Hôte: Souris Monoclonal 2D6 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (N-Term) antibodyTNFRSF10B Reactivité: Humain WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 266-393) antibodyTNFRSF10B Reactivité: Humain IHC Hôte: Souris Monoclonal DR5-3381 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 56-210) antibodyTNFRSF10B Reactivité: Humain ELISA Hôte: Souris Monoclonal 2H5B8 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) antibodyTNFRSF10B Reactivité: Humain, Souris WB, ICC Hôte: Souris Monoclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (C-Term) antibodyTNFRSF10B Reactivité: Humain, Souris WB, IHC, ICC, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
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Indications d'application
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Flow Cytometry: 1-10 μg/mLPositive control: JURKAT human peripheral blood leukemia T cell line.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Concentration
- 1.0 mg/mL
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Buffer
- PBS, pH 7.4 with 15 mM Sodium Azide as preservative.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
Date de péremption
- 12 months
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- TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
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Autre désignation
- CD262 / TRAILR2
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Sujet
- TRAIL-R2 (CD262, DR5) is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L). Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including tumor necrosis factor (TNF) and Fas ligand in the TNF family through their death domain containing receptors, TNF receptor 1 (TNFR1) and Fas, respectively. Another member in the TNF family has been identified and designated TRAIL (for TNF related apoptosis inducing ligand) and Apo2L (for Apo2 ligand). Receptors for TRAIL include two death domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. DcR1 (also called TRID), like the related death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intracellular death domain and is thus incapable of signaling apoptosis. It has been suggested DcR1 is responsible for TRAIL resistance in normal human tissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow. DR5 is a member of the TNF receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor related apoptosis inducing ligand (TNFSF10/TRAIL/APO2L), and transduces apoptosis signal. Studies with FADD deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.Synonyms: DR5, Death receptor 5, KILLER, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAIL-R2, TRICK2, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9
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ID gène
- 8795
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UniProt
- O14763
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Pathways
- Signalisation p53, Apoptose, Positive Regulation of Endopeptidase Activity
Antigène
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