BMPR2 anticorps (AA 803-996)
(3 références)Aperçu rapide pour BMPR2 anticorps (AA 803-996) (ABIN968806)
Antigène
Voir toutes BMPR2 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- AA 803-996
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Réactivité croisée
- Humain, Rat (Rattus)
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Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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Immunogène
- Mouse BMPR-II aa. 803-996
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Isotype
- IgG1
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anti-Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) antibody
BMPR2 Reactivité: Humain, Souris, Rat, Singe WB, ELISA, IHC Hôte: Souris Monoclonal 1F12 unconjugated
anti-Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) antibodyBMPR2 Reactivité: Humain, Souris, Rat, Singe WB, ELISA, IHC, ICC Hôte: Souris Monoclonal 3F6 unconjugated
anti-Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) (AA 28-59) antibodyBMPR2 Reactivité: Humain WB, ELISA, IHC, FACS Hôte: Lapin Polyclonal unconjugated
anti-Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) (AA 28-59), (N-Term) antibodyBMPR2 Reactivité: Humain WB, FACS, IHC (p) Hôte: Lapin Polyclonal RB01778 unconjugated
anti-Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) (AA 27-150) antibodyBMPR2 Reactivité: Humain WB, IF Hôte: Lapin Polyclonal unconjugated
anti-Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) (AA 27-150) antibodyBMPR2 Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) (AA 27-150) antibodyBMPR2 Reactivité: Humain WB, ELISA, IHC (p), ICC, IHC (fro) Hôte: Lapin Polyclonal unconjugated
anti-Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) (C-Term) antibodyKO Validated BMPR2 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) (Internal Region) antibodyBMPR2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
anti-Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) (AA 27-56), (N-Term) antibodyBMPR2 Reactivité: Humain FACS, IHC (p) Hôte: Lapin Polyclonal RB1806 unconjugated
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Commentaires
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Related Products: ABIN968540, ABIN967389
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 250 μg/mL
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Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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Stockage commentaire
- Store undiluted at -20°C.
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: "Type I collagen induces expression of bone morphogenetic protein receptor type II." dans: Biochemical and biophysical research communications, Vol. 283, Issue 2, pp. 316-22, (2001) (PubMed).
: "Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension." dans: Nature genetics, Vol. 26, Issue 1, pp. 81-4, (2000) (PubMed).
: "Cloning and characterization of a human type II receptor for bone morphogenetic proteins." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 17, pp. 7632-6, (1995) (PubMed).
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- BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))
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Autre désignation
- BMPR-II
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Sujet
- The transforming growth factor beta (TGFbeta)/activin/BMP family of growth factor plays a diverse and important role in growth, development, and differentiation. The receptors for this famiy of proteins are type I and II ser/thr kinase receptors. Bone morphogenetic protein receptors (BMPRs) include two type I receptors, BMPR-IA and BMPR-IB, and a type II receptor, BMPR-II. BMPR-II is a widely expressed receptor, with high mRNA expression during development in many tissues. BMPR-II transfected COS-1 cells show binding to BMP-7 (osteogenic protein-1) and BMP-4, and co-transfection with the type I receptor, ActR-I, leads to transcriptional activation in response to BMP-7. In addition, extracellular matrix proteins may regulate the expression of BMPR-II during angiogenesis, since fibrillar type I collagen induces BMPR-II expression in endothelial cells. In familial primary pulmonary hypertension, the BMPR-II gene is mutated in a manner that may disrupt ligand binding, kinase activity, and heteromeric dimer formation. Thus, BMPR-II may be an important mediator of BMP effects during growth and differentiation of endothelial cells.
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Poids moléculaire
- 130 kDa
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Pathways
- Growth Factor Binding
Antigène
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