BMPR2 anticorps (N-Term)

N° du produit ABIN388741

Détail du produit anti-BMPR2 anticorps

Antigène: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Épitope: AA 28-59, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BMPR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This BMPR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the N-terminal region of human BMPR2.

Clone: RB01778

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Références pour anticorps anti-BMPR2 (ABIN388741)

Lynch, Ahsan: "Correlating the Effects of Bone Morphogenic Protein to Secreted Soluble Factors from Fibroblasts and Mesenchymal Stem Cells in Regulating Regenerative Processes In Vitro." dans: Tissue engineering. Part A, (2014) (PubMed).

Srikanth, Kim, Das, Kessler: "BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells." dans: Molecular cancer research : MCR, Vol. 12, Issue 2, pp. 283-94, (2014) (PubMed).

Li, Cao, Ma, Wang, Zhang, Luo, Chen, Wu, Meng, Zhang, Yuan, Ma, Huang: "Roles of miR-1-1 and miR-181c in ventricular septal defects." dans: International journal of cardiology, Vol. 168, Issue 2, pp. 1441-6, (2013) (PubMed).

Zhang, Mu, Zhou, Vrijens, Roussel, Jiang, Yan: "Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors." dans: Cell death & disease, Vol. 3, pp. e308, (2012) (PubMed).

Jara, Chacón, Burgos, Droguett, Valdivieso, Ortiz, Troncoso, Mezzano: "Expression of gremlin, a bone morphogenetic protein antagonist,is associated with vascular calcification in uraemia." dans: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 24, Issue 4, pp. 1121-9, (2009) (PubMed).

Sehgal, Mukhopadhyay, Xu, Patel, Shah: "Dysfunction of Golgi tethers, SNAREs, and SNAPs in monocrotaline-induced pulmonary hypertension." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 292, Issue 6, pp. L1526-42, (2007) (PubMed).

Ramos, Lamé, Segall, Wilson: "The BMP type II receptor is located in lipid rafts, including caveolae, of pulmonary endothelium in vivo and in vitro." dans: Vascular pharmacology, Vol. 44, Issue 1, pp. 50-9, (2005) (PubMed).

Détails sur BMPR2

Antigène: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Autre désignation: BMPR2 (BMPR2 Produits)

Synonymes: anticorps BMPR-II, anticorps BMPR3, anticorps BMR2, anticorps BRK-3, anticorps PPH1, anticorps T-ALK, anticorps 2610024H22Rik, anticorps AL117858, anticorps AW546137, anticorps BB189135, anticorps BMP-2, anticorps BMPR-2, anticorps BMPRII, anticorps Gm20272, anticorps Bmpr-II, anticorps bmprii, anticorps bone morphogenetic protein receptor type 2, anticorps bone morphogenetic protein receptor, type II b (serine/threonine kinase), anticorps bone morphogenetic protein receptor, type II (serine/threonine kinase), anticorps BMPR2, anticorps bmpr2b, anticorps Bmpr2

Sujet: BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension.

Poids moléculaire: 115201

ID gène: 659

NCBI Accession: NP_001195

UniProt: Q13873

Pathways: Growth Factor Binding