APBB1
Reactivité: Souris, Humain, Rat, Boeuf (Vache), Chien, Cobaye, Lapin, Roussette (Chauve-souris)
WB
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Optimal working dilutions should be determined experimentally by the investigator.
Restrictions
For Research Use only
Format
Liquid
Stock
-20 °C
Antigène
FE65 (APBB1)
(Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
Autre désignation
anti-Fe65
Sujet
Amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer's disease (AD). FE65 is a signaling adaptor of APP protein. The FE65/APP complex was shown to translocate into the cell nucleus and regulate gene expression. Genetic studies in mice validated FE65-APP interaction and molecular studies provided evidence on the role of the complex in abnormal signaling detected in brains of Alzheimer Disease patients.