FE65 anticorps (N-Term)

N° du produit ABIN928785

Détail du produit anti-FE65 anticorps

Antigène: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Épitope: N-Term

Reactivité: Souris, Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FE65 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Souris

Purification: Purified

Immunogène: Apbb1 antibody was raised in rabbit using the N terminal of Apbb1 as the immunogen

Information d'application

Indications d'application: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Commentaires:

Apbb1 Blocking Peptide, catalog no. 33R-1963, is also available for use as a blocking control in assays to test for specificity of this Apbb1 antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Détails sur FE65

Antigène: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Autre désignation: Apbb1 (APBB1 Produits)

Synonymes: anticorps FE65, anticorps MGC:9072, anticorps RIR, anticorps apbb1, anticorps MGC80654, anticorps Fe65, anticorps Rir, anticorps amyloid beta precursor protein binding family B member 1, anticorps amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog, anticorps amyloid beta (A4) precursor protein-binding, family B, member 1, anticorps APBB1, anticorps apbb1.L, anticorps Apbb1

Sujet: Apbb1 is an adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain.Apbb1 plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. Apbb1 may act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Synonyms: Polyclonal Apbb1 antibody, Anti-Apbb1 antibody, amyloid beta, A4 precursor protein-binding, family B, member 1 antibody, Fe65 antibody, Rir antibody.

Pathways: Positive Regulation of Response to DNA Damage Stimulus