PUMA anticorps
Aperçu rapide pour PUMA anticorps (ABIN308637)
Antigène
Voir toutes PUMA (BBC3) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Réactivité croisée
- Humain
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Purification
- affinity purified
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Immunogène
- Reacts with a 17 residue sequence [EQHLESPVPSAPGALAG] found in the exon-3-encoded region in the human PUMA-alpha and PUMA-beta forms of the protein. Recognizes both forms of the protein.
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Isotype
- IgG
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anti-BCL2 Binding Component 3 (BBC3) (AA 131-180) antibody
BBC3 Reactivité: Humain, Rat, Porc WB, ELISA, IP, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 119-154) antibodyBBC3 Reactivité: Humain WB, IF, FACS, IHC (p) Hôte: Lapin Polyclonal RB01353 unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 119-154) antibodyBBC3 Reactivité: Humain WB, ELISA, IHC, IF, FACS Hôte: Lapin Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (BH3 Domain), (C-Term) antibodyBBC3 Reactivité: Humain, Souris WB, IF, FACS, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (N-Term) antibodyBBC3 Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 98-152) antibodyBBC3 Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 5D10 unconjugated
anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibodyBBC3 Reactivité: Humain, Souris WB, IHC, ICC, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 186-199) antibodyBBC3 Reactivité: Humain WB, IHC, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 2-16) antibodyBBC3 Reactivité: Humain, Rat, Souris WB, IHC, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) antibodyBBC3 Reactivité: Humain WB, FACS Hôte: Lapin Monoclonal 23GB1935 unconjugated Recombinant Antibody
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Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Stock
- -20 °C
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- PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
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Autre désignation
- PUMA
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Sujet
- A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway. In human and mouse, PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53.
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Pathways
- Signalisation p53, Positive Regulation of Endopeptidase Activity
Antigène
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