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BRCA1 anticorps

Il existe 5+ publications pour ce produit. L’anticorps anti-BRCA1 Polyclonal Lapin est utilisé pour la détection de BRCA1 dans des échantillons de Humain. Il a été validé pour IHC.
N° du produit ABIN965696
411,13 €
Plus frais de livraison 40,00 € et TVA
100 μg
Destination: France
Envoi sous 8 à 12 jours ouvrables

Aperçu rapide pour BRCA1 anticorps (ABIN965696)

Antigène

Voir toutes BRCA1 Anticorps
BRCA1 (Breast Cancer 1 (BRCA1))

Reactivité

  • 233
  • 39
  • 30
  • 3
  • 2
  • 1
  • 1
  • 1
Humain

Hôte

  • 184
  • 58
  • 1
Lapin

Clonalité

  • 178
  • 65
Polyclonal

Conjugué

  • 111
  • 19
  • 10
  • 6
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
Cet anticorp BRCA1 est non-conjugé

Application

  • 125
  • 71
  • 54
  • 48
  • 41
  • 39
  • 31
  • 26
  • 25
  • 15
  • 13
  • 8
  • 8
  • 8
  • 3
  • 2
  • 2
  • 2
  • 1
Immunohistochemistry (IHC)
  • Specificité

    BRCA1 (Ab-1423) antibody detects endogenous levels of total BRCA1 protein.

    Purification

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    Immunogène

    The antiserum was produced against synthesized non-phosphopeptide derived from human BRCA1 around the phosphorylation site of serine 1423 (H-G-SP-Q-P).
  • Indications d'application

    IHC: 1:50-1:100.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    100ug/100ul.

    Buffer

    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

    Agent conservateur

    Sodium azide

    Précaution d'utilisation

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Stock

    -20 °C
  • Greenberg, Sobhian, Pathania, Cantor, Nakatani, Livingston: "Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes." dans: Genes & development, Vol. 20, Issue 1, pp. 34-46, (2006) (PubMed).

    Arlt, Xu, Durkin, Casper, Kastan, Glover: "BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function." dans: Molecular and cellular biology, Vol. 24, Issue 15, pp. 6701-9, (2004) (PubMed).

    Zhang, Willers, Feng, Ghosh, Kim, Weaver, Chung, Powell, Xia: "Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair." dans: Molecular and cellular biology, Vol. 24, Issue 2, pp. 708-18, (2003) (PubMed).

    Kim, Xu, Kastan: "Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage." dans: Genes & development, Vol. 16, Issue 5, pp. 560-70, (2002) (PubMed).

    Tibbetts, Cortez, Brumbaugh, Scully, Livingston, Elledge, Abraham: "Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress." dans: Genes & development, Vol. 14, Issue 23, pp. 2989-3002, (2000) (PubMed).

  • Antigène

    BRCA1 (Breast Cancer 1 (BRCA1))

    Autre désignation

    BRCA1

    Pathways

    Cycle Cellulaire, Réparation de l'ADN, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
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