CD4 anticorps
Aperçu rapide pour CD4 anticorps (ABIN498108)
Antigène
Voir toutes CD4 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Specificité
- This antibody antibody detects endogenous levels of CD4 protein (region surrounding Ala429).
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Réactivité croisée (Details)
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human. -
Purification
- Affinity Chromatography using epitope-specific immunogen
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anti-CD4 (CD4) (AA 385-457) antibody
CD4 Reactivité: Humain, Souris, Rat, Poulet, Porc FACS, WB, ELISA, IHC (fro), IHC (p), IF (cc), IF (p) Hôte: Lapin Polyclonal unconjugated
anti-CD4 (CD4) antibodyCD4 Reactivité: Humain, Souris, Rat, Poulet, Singe, Chien, Porc, Lapin, Boeuf (Vache), Mouton, Cobaye, Chévre, Cheval, Avian, Âne, Hamster WB, IHC (fro), IHC (p) Hôte: Chèvre Polyclonal unconjugated
anti-CD4 (CD4) (AA 231-330) antibodyCD4 Reactivité: Humain, Souris, Rat FACS, WB, ELISA, IHC (fro), IHC (p), IF (cc), IF (p) Hôte: Lapin Polyclonal unconjugated
anti-CD4 (CD4) (N-Term) antibodyCD4 Reactivité: Humain FACS, WB, MS Hôte: Souris Monoclonal MEM-241 unconjugated
anti-CD4 (CD4) antibodyCD4 Reactivité: Humain, Souris, Rat IHC Hôte: Souris Monoclonal unconjugated
anti-CD4 (CD4) (AA 301-400) antibodyCD4 Reactivité: Humain, Souris, Rat FACS, WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-CD4 (CD4) (AA 26-200) antibodyCD4 Reactivité: Humain WB, IF Hôte: Lapin Polyclonal unconjugated
anti-CD4 (CD4) antibody (PE)CD4 Reactivité: Rat FACS Hôte: Souris Monoclonal OX-35 PE
anti-CD4 (CD4) antibodyCD4 Reactivité: Souris FACS, IP, IHC (fro), ICC, Func Hôte: Rat Monoclonal GK1-5 unconjugated
anti-CD4 (CD4) (N-Term) antibody (FITC)CD4 Reactivité: Humain FACS Hôte: Souris Monoclonal MEM-241 FITC
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Indications d'application
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Western Blots: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200. Immunofluorescence: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Concentration
- 1.0 mg/mL
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Buffer
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freezing and thawing.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CD4
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Autre désignation
- CD4
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Sujet
- Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen-Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR-antigen interaction, prolongs the contact between the T cell and the antigen presenting cell and recruits the tyrosine kinase Lck, which is essential for T cell activation.Synonyms: T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4
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Poids moléculaire
- approx. 51 kDa
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ID gène
- 920
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NCBI Accession
- NP_000607
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UniProt
- P01730
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Pathways
- TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events
Antigène
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