CDKN1B anticorps (C-Term)
(1 reference)Aperçu rapide pour CDKN1B anticorps (C-Term) (ABIN504595)
Antigène
Voir toutes CDKN1B AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- C-Term
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Séquence
- EQCAGIRKRP ATDDSSTQNK RANRTEENVS DGSPNAGSVE QTPKKPGLRR
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Homologie
- Human: 100%
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Attributs du produit
- This is a rabbit polyclonal antibody against CDKN1B. It was validated on Western Blot using a cell lysate as a positive control.
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Purification
- Affinity Purified
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Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human CDKN1B
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anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (AA 1-198) antibody
CDKN1B Reactivité: Humain WB, ELISA, IF, IHC (p), PLA Hôte: Souris Monoclonal 4B4-E6 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (AA 150-198) antibodyCDKN1B Reactivité: Humain, Souris, Rat WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) antibodyKO Validated CDKN1B Reactivité: Humain WB, IHC, IF, IHC (p), IP, ICC, IHC (fro) Hôte: Lapin Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) antibodyCDKN1B Reactivité: Humain, Souris, Rat, Singe WB, IHC, IF, FACS Hôte: Souris Monoclonal SX53G8 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) antibodyKD Validated CDKN1B Reactivité: Humain WB, FACS, ICC Hôte: Lapin Monoclonal 23GB1825 unconjugated Recombinant Antibody
anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) antibodyCDKN1B Reactivité: Humain, Souris, Rat WB, IF, FACS, IHC (p) Hôte: Souris Monoclonal DCS-72-F6-KIP1-769 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (AA 1-198) antibodyCDKN1B Reactivité: Humain WB, IF Hôte: Souris Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (pThr187) antibodyCDKN1B Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) antibodyCDKN1B Reactivité: Humain, Souris, Rat, Singe WB, IHC, IF, FACS Hôte: Souris Monoclonal DCS-72-F6 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) antibodyCDKN1B Reactivité: Humain WB, IHC, ELISA, IF Hôte: Lapin Monoclonal 1G2 unconjugated Recombinant Antibody
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Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
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Commentaires
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Antigen size: 198 AA
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- Lot specific
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Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort." dans: Breast cancer research : BCR, Vol. 10, Issue 3, pp. R47, (2008) (PubMed).
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- CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
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Autre désignation
- CDKN1B
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Sujet
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CDKN1B is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Protein Interaction Partner: CCND1, UBC, SGK1, PSMB1, CDK4, SKP2, CDK5, CDK3, CDK2, CDK1, SKP1, CKS1B, CCNE1, CCND3, CAMK1, YWHAQ, CCNA2, ABL1, TSC2, LYN, STMN1, RHOA, RPS6KA1, IRF1, KPNA6, CCNE2, CCNA1, VCP, SRC, MAPK10, MAPK8, CDC34, CDK6, RCHY1, COPS5, CUL1, HIST1H1A, CUL4A, JAK2,
Protein Size: 198 -
Poids moléculaire
- 22 kDa
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ID gène
- 1027
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NCBI Accession
- NM_004064, NP_004055
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UniProt
- P46527
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Pathways
- Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy
Antigène
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