CYP27B1 anticorps (C-Term)
(4 références)Aperçu rapide pour CYP27B1 anticorps (C-Term) (ABIN652999)
Antigène
Voir toutes CYP27B1 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- AA 482-508, C-Term
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Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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Immunogène
- This CYP27B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-508 amino acids from the C-terminal region of human CYP27B1.
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Isotype
- Ig Fraction
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anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 256-508) antibody
CYP27B1 Reactivité: Humain WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 251-500) antibodyCYP27B1 Reactivité: Rat WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 475-508), (C-Term) antibodyCYP27B1 Reactivité: Humain, Rat, Souris WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 258-504) antibodyCYP27B1 Reactivité: Souris WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 477-508), (C-Term) antibodyCYP27B1 Reactivité: Humain WB Hôte: Souris Monoclonal 1981CT820-303-81 unconjugated
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 400-429), (C-Term) antibodyCYP27B1 Reactivité: Souris WB Hôte: Lapin Polyclonal RB31024 unconjugated
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 1-75) antibodyCYP27B1 Reactivité: Poisson zèbre (Danio rerio) WB, ELISA Hôte: Lapin Polyclonal unconjugated
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 350-491) antibodyCYP27B1 Reactivité: Humain WB, ELISA Hôte: Lapin Polyclonal unconjugated
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Indications d'application
- WB: 1:500. WB: 1:2000. IHC-P: 1:10~50. FC: 1:25
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid freeze-thaw cycles.
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Stock
- 4 °C,-20 °C
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Stockage commentaire
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
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Date de péremption
- 6 months
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: "25(OH)D Is Effective to Repress Human Cholangiocarcinoma Cell Growth through the Conversion of 25(OH)D to 1α,25(OH)₂D₃." dans: International journal of molecular sciences, Vol. 17, Issue 8, (2016) (PubMed).
: "Reduced sinonasal levels of 1?-hydroxylase are associated with worse quality of life in chronic rhinosinusitis with nasal polyps." dans: International forum of allergy & rhinology, (2015) (PubMed).
: "Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1?-hydroxylase expression in the developing rat." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 309, Issue 9, pp. L1018-26, (2015) (PubMed).
: "Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis." dans: The Journal of allergy and clinical immunology, Vol. 134, Issue 2, pp. 342-349.e1, (2014) (PubMed).
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- CYP27B1 (Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1))
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Autre désignation
- CYP27B1
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Sujet
- CYP27B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
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Poids moléculaire
- 56504
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ID gène
- 1594
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NCBI Accession
- NP_000776
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UniProt
- O15528
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Pathways
- Metabolism of Steroid Hormones and Vitamin D
Antigène
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