Cité dans 2 publications.
Cet anticorps anti-GCN2 Polyclonal Lapin (Clone RB8239) (ABIN391197) détecte spécifiquement GCN2 dans WB et IHC (p).
L’anticorps est réactif avec des échantillons de Humain.
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This GCN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GCN2.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption
6 months
Fougeray, Mami, Bertho, Beaune, Thervet, Pallet: "Tryptophan depletion and the kinase GCN2 mediate IFN-?-induced autophagy." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 6, pp. 2954-64, (2012) (PubMed).
Lu, László, Miao, Chen, Wu: "The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2." dans: The Journal of biological chemistry, Vol. 284, Issue 36, pp. 24281-8, (2009) (PubMed).
GCN2 (EIF2AK4) belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses.