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ERBB3 anticorps (pTyr1328)

Cet anticorps Lapin Polyclonal détecte spécifiquement ERBB3 dans WB, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Image no. 1 for anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pTyr1328) antibody (ABIN319274) (ERBB3 anticorps (pTyr1328))

Image no. 2 for anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pTyr1328) antibody (ABIN319274) (ERBB3 anticorps (pTyr1328))

Image no. 3 for anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pTyr1328) antibody (ABIN319274) (ERBB3 anticorps (pTyr1328))

4 images

N° du produit ABIN319274

483,08 €

Plus frais de livraison 40,00 € et TVA

Destination: France

Envoi sous 17 jours ouvrables

Aperçu rapide pour ERBB3 anticorps (pTyr1328) (ABIN319274)

Antigène

Voir toutes ERBB3 Anticorps

ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Reactivité

Humain, Souris, Rat

Hôte

Lapin

Clonalité

Polyclonal

Conjugué

Cet anticorp ERBB3 est non-conjugé

Application

Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Discover our top product ERBB3 Anticorps primaire

Épitope
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pTyr1328

Specificité

Antibody AP08032PU detects endogenous levels of Her3/ErbB3 only when phosphorylated at Tyrosine 1328.

Purification

Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Immunogène

The antiserum was produced against synthesized phosphopeptide derived from human Her3/ErbB3 around the phosphorylation site of Tyrosine 1328 (P-D-YP-W-H).
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 707-964) antibody
ERBB3 Reactivité: Souris WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 24-55), (N-Term) antibody
ERBB3 Reactivité: Humain, Souris WB, FACS, IHC (p) Hôte: Lapin Polyclonal RB01467 unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (C-Term) antibody
ERBB3 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 1-130) antibody
ERBB3 Reactivité: Humain WB, ELISA, IHC (p) Hôte: Souris Monoclonal 2E9 unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pTyr1289) antibody
ERBB3 Reactivité: Humain, Souris, Rat WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) antibody
ERBB3 Reactivité: Humain WB, IP, IHC (fro), IHC (f) Hôte: Souris Monoclonal RTJ-1 unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 24-55) antibody
ERBB3 Reactivité: Humain, Souris WB, IHC, ELISA, FACS Hôte: Lapin Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (C-Term) antibody
Verified ERBB3 Reactivité: Humain IHC, ELISA, IF, FACS Hôte: Chèvre Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 21-332) antibody
ERBB3 Reactivité: Humain IHC, ELISA, IHC (p) Hôte: Souris Monoclonal 3F12 unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 1-131) antibody
ERBB3 Reactivité: Humain WB, IHC, ELISA, IHC (p) Hôte: Souris Monoclonal 2E9 unconjugated

Indications d'application

Western Blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions

For Research Use only
Concentration

1.0 mg/mL

Buffer

PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation

Avoid repeated freezing and thawing.

Stock

-20 °C

Stockage commentaire

Store the antibody (in aliquots) at-20 °C.
Antigène

ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Autre désignation

ERBB3 / HER3

Sujet

The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.Synonyms: ERBB-3, HER-3, Proto-oncogene-like protein c-ErbB-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, c-erbB-3

ID gène

2065

NCBI Accession

NP_001005915

UniProt

P21860

Pathways

Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway