ERCC2 anticorps (C-Term)
(1 reference)Aperçu rapide pour ERCC2 anticorps (C-Term) (ABIN966088)
Antigène
Voir toutes ERCC2 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- C-Term
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Purification
- Purified by antigen-specific affinity chromatography.
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Immunogène
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ERCC2(TFIIH basal transcription factor complex helicase subunit)
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anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) antibody
KD Validated ERCC2 Reactivité: Humain WB, FACS, IF (p) Hôte: Lapin Monoclonal 25GB2260 unconjugated Recombinant Antibody
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (Internal Region) antibodyERCC2 Reactivité: Humain, Souris WB, IF, ICC, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) antibodyERCC2 Reactivité: Humain WB, IHC Hôte: Lapin Monoclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-300) antibodyERCC2 Reactivité: Humain WB, IHC, ELISA Hôte: Lapin Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-405) antibodyERCC2 Reactivité: Humain WB, IF, ELISA Hôte: Souris Monoclonal S3 unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-300) antibodyERCC2 Reactivité: Humain IHC, ELISA Hôte: Lapin Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 631-730) antibodyERCC2 Reactivité: Humain IF, ELISA Hôte: Souris Monoclonal 2C9 unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-760) antibodyERCC2 Reactivité: Humain WB, IF Hôte: Souris Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-760) antibodyERCC2 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 79-295) antibodyERCC2 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, FACS Hôte: Lapin Polyclonal unconjugated
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Indications d'application
- ELISA, Western blotting: 1µg/ml for 2hrs.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- This antibody is stored in PBS, 50% glycerol
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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: "Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH." dans: Nature genetics, Vol. 20, Issue 2, pp. 184-8, (1998) (PubMed).
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- ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
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Autre désignation
- ERCC2
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Sujet
- ERCC2(TFIIH basal transcription factor complex helicase subunit) is an ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. ERCC2 is involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. ERCC2 might also have a role in aging process and could play a causative role in the generation of skin cancers. One of the six subunits forming the core-TFIIH basal transcription factor. The interaction with p44 results in the stimulation of the 5'-->3' helicase activity. Defects in ERCC2 are the cause of xeroderma pigmentosum complementation group D (XP-D), xeroderma pigmentosum group D combined with Cockayne syndrome (XP-D/CS). Defects in ERCC2 are a cause of trichothiodystrophy (TTD) and COFS syndrome. ERCC2 belongs to the helicase family and RAD3/XPD subfamily.
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Pathways
- Réparation de l'ADN
Antigène
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