SLC22A1 anticorps (C-Term)
(3 références)Aperçu rapide pour SLC22A1 anticorps (C-Term) (ABIN966708)
Antigène
Voir toutes SLC22A1 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- C-Term
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Immunogène
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human OCT1 (Organic cation transporter 1)
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anti-Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) (AA 413-671) antibody
SLC22A1 Reactivité: Humain WB, IHC, ICC, IP Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) antibodySLC22A1 Reactivité: Humain, Souris, Rat WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) antibodySLC22A1 Reactivité: Humain ELISA, FACS Hôte: Souris Monoclonal 2C5 unconjugated
anti-Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) (AA 128-391) antibodySLC22A1 Reactivité: Souris WB, IHC, ICC, IP Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) antibodySLC22A1 Reactivité: Humain, Souris, Rat, Chien WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) (AA 511-539), (C-Term) antibodySLC22A1 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB22501 unconjugated
anti-Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) (AA 43-149) antibodySLC22A1 Reactivité: Humain IHC, ELISA Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) (AA 100-149) antibodySLC22A1 Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin, Roussette (Chauve-souris), Porc WB Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) (C-Term) antibodySLC22A1 Reactivité: Humain WB, IHC, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) antibodySLC22A1 Reactivité: Humain WB, FACS Hôte: Lapin Monoclonal 24GB2510 unconjugated Recombinant Antibody
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Restrictions
- For Research Use only
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Stock
- 4 °C
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: "Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1)." dans: Annals of human genetics, Vol. 63, Issue Pt 6, pp. 473-82, (2001) (PubMed).
: "Cloning and characterization of two human polyspecific organic cation transporters." dans: DNA and cell biology, Vol. 16, Issue 7, pp. 871-81, (1997) (PubMed).
: "Cloning and functional expression of a human liver organic cation transporter." dans: Molecular pharmacology, Vol. 51, Issue 6, pp. 913-21, (1997) (PubMed).
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- SLC22A1 (Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1))
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Autre désignation
- OCT1 (SLC22A1)
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Sujet
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OCT1 (Organic cation transporter 1) translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine.Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase. OCT1 is widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines. In the liver activated by HNF4A and suppressed by bile acids via NR0B2. Increased by cholesterol treatment in hepatocyte cells. OCT1 belongs to the major facilitator superfamily and organic cation transporter family.
Synonyms: SLC22A1(Solute carrier family 22 member 1) -
Pathways
- Hormone Transport
Antigène
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