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anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Anticorps

The protein encoded by APBA1 is a member of the X11 protein family. De plus, nous expédions et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
APBA1 319924 B2RUJ5
APBA1 83589 O35430
APBA1 320 Q02410
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Top anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 81 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Chèvre Inconjugué ELISA, WB ABIN190802 (0.1µg/ml) staining of Human Brain (Cerebellum) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 3 to 4 Days
349,82 €
Détails
Humain Lapin Inconjugué EIA, IF, WB Western blot analysis of APBA1 in rat brain tissue lysate with APBA1 Antibody  at 0.5 µg/ml in (A) the absence and (B) the presence of blocking peptide. 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Chèvre Inconjugué WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Souris Souris Inconjugué IF, IHC, WB Western blot analysis of Mint1 on a rat cerebrum lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti-Mint1 antibody. Immunofluorescence staining of rat neurons. 50 μg Connectez-vous pour afficher 2 to 4 Days
195,64 €
Détails
Humain Chèvre Inconjugué ELISA, WB Western Blot: APBA1 Antibody [NBP1-06015] - (0.1ug/ml) staining of Human Brain (Cerebellum) 35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Connectez-vous pour afficher 3 to 5 Days
388,75 €
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of UROP11 in mouse spleen tissue lysate with this product at (A) 1 and (B) 2 μg/ml. 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Lapin Inconjugué IHC, WB WB Suggested Anti-APBA1 Antibody Titration: 0.2-1 ug/mlPositive Control: Raji cell lysate 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Rat Lapin Inconjugué ICC, IHC, WB dilution: 1 : 1000, sample: rat hippocampus homogenate Indirect immunostaining of rat hippocampus neurons with anti-Mint 1 (dilution 1 : 200; red) and anti-synapsin (cat. no. 106 001; dilution 1 : 500, green). 50 μg Connectez-vous pour afficher 2 to 3 Days
341,00 €
Détails
Humain Chèvre Inconjugué ELISA, WB 0.1 mg Connectez-vous pour afficher 6 to 8 Days
505,48 €
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, WB Western Blot: APBA1 Antibody [NBP2-41182] - Analysis of APBA1 in rat brain tissue lysate with APBA1 antibody at 0.5 ug/ml in (A) the absence and (B) the presence of blocking peptide. Immunocytochemistry/Immunofluorescence: APBA1 Antibody [NBP2-41182] - Human brain tissue with APBA1 antibody at 20 ug/mL. 0.1 mg Connectez-vous pour afficher 4 to 7 Days
426,25 €
Détails

APBA1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Anticorps mieux référencés

  1. Mouse (Murine) Monoclonal APBA1 Primary Antibody pour IF, IHC - ABIN968327 : Biederer, Südhof: Mints as adaptors. Direct binding to neurexins and recruitment of munc18. dans The Journal of biological chemistry 2001 (PubMed)
    Show all 4 references for ABIN968327

  2. Human Polyclonal APBA1 Primary Antibody pour EIA, IF - ABIN1450013 : Borg, Ooi, Levy, Margolis: The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. dans Molecular and cellular biology 1996 (PubMed)
    Show all 4 references for ABIN1450013

  3. Human Polyclonal APBA1 Primary Antibody pour ELISA, WB - ABIN190802 : Jacobs, Williams, Francis: Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease. dans Neuroscience 2006 (PubMed)

  4. Human Polyclonal APBA1 Primary Antibody pour EIA, WB - ABIN501114 : Verlaeten, Casery, Cavagna, Naville, Giraudon, Belin, Begeot, Bernard: Identification of Urop11, a novel leptin-modulated gene that is upregulated in the hypothalamus of mice with virus-induced obesity. dans Journal of molecular endocrinology 2007 (PubMed)

Plus d’anticorps contre Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 partenaires d’interaction

Mouse (Murine) Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) interaction partners

  1. Due to the multiple interacting partners of X11alpha, dysfunction or alteration in X11alpha will have a significant cellular effect.

  2. Mint1 826 bridges APP (Montrer APP Anticorps) to the small GTPase (Montrer RACGAP1 Anticorps)

  3. Expression of Apba1 in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR (Montrer UTS2R Anticorps) of Comt (catechol-O-methyltransferase (Montrer COMT Anticorps)).

  4. Our data support a function for both GSK3 (Montrer GSK3b Anticorps) and CDK5 (Montrer CDK5 Anticorps) in amyloid precursor protein (Montrer APP Anticorps) processing, further implicating these two kinases in the pathogenesis of Alzheimer's disease.

  5. Can be considered a key molecule in the hypothalamic integration pathway, important as a target of leptin (Montrer LEP Anticorps) action.

  6. Reports have demonstrated that KIF17 (Montrer KIF17 Anticorps)-Mint1 association was disrupted and transported cargo was released from its microtubule-based transport when Ser (Montrer SIGLEC1 Anticorps) 1029 of KIF17 (Montrer KIF17 Anticorps) was phosphorylated.

  7. X11s associate primarily with APP (Montrer APP Anticorps) molecules that are outside of DRM (Montrer GREM1 Anticorps), that the dissociation of APP (Montrer APP Anticorps)-X11/X11L (Montrer APBA2 Anticorps) complexes leads to entry of APP (Montrer APP Anticorps) into DRM (Montrer GREM1 Anticorps), and that cleavage of uncomplexed APP (Montrer APP Anticorps) by BACE (Montrer BACE Anticorps) within DRM (Montrer GREM1 Anticorps)

  8. These results suggest that the three Mint/X11 proteins regulate Abeta (Montrer APP Anticorps) production by a novel mechanism that may have implications for therapeutic approaches to altering APP (Montrer APP Anticorps) cleavage in Alzheimer's disease.

Human Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) interaction partners

  1. Mints are necessary for activity-induced APP (Montrer APP Anticorps) and PS1 (Montrer PSEN1 Anticorps) trafficking and provide insight into the cellular fate of APP (Montrer APP Anticorps) in endocytic pathways essential for Abeta (Montrer APP Anticorps) production.

  2. Mint1 826 bridges APP (Montrer APP Anticorps) to the small GTPase (Montrer RACGAP1 Anticorps)

  3. an autoinhibitory mechanism in Mint1 is important for regulating APP (Montrer APP Anticorps) processing and may provide novel therapies for Alzheimer's disease

  4. Transcriptional co-activators Taz (Montrer TAZ Anticorps) and Yap (Montrer YAP1 Anticorps) mediate signaling via the amyloid beta protein precursor paralogues APLP1 (Montrer APLP1 Anticorps) and APLP2 (Montrer APLP2 Anticorps) through interactions with Mint1 and Mint3 (Montrer APBA3 Anticorps).

  5. Study identified the conserved binding site for the peptide on the CASK (Montrer CASK Anticorps) calmodulin (Montrer CALM1 Anticorps) kinase domain. A related EPIWVMRQ peptide from Mint1 was also discovered to be sufficient for binding.

  6. Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis.

  7. Methylation of MINT1 was significantly more prevalent in UC-CRC (Montrer CALR Anticorps) cases compared with controls.

  8. ApoEr2 (Montrer LRP8 Anticorps) regulates cell movement, and both X11alpha and Reelin (Montrer RELN Anticorps) enhance this effect.

  9. A novel consensus sequence for interaction with the PDZ (Montrer INADL Anticorps)-1 and PDZ (Montrer INADL Anticorps)-2 domains of amyloid precursor protein (APP (Montrer APP Anticorps))-interacting proteins Mint1, Mint2 (Montrer APBA2 Anticorps), and Mint3 (Montrer APBA3 Anticorps) is reported, with multiple novel interactors for these proteins.

  10. Munc18a acts through direct and indirect interactions with X11 proteins and powerfully regulates APP (Montrer APP Anticorps) metabolism and Abeta (Montrer APP Anticorps) secretion.

Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) profil antigène

Profil protéine

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.

Gene names and symbols associated with APBA1

  • amyloid beta (A4) precursor protein-binding, family A, member 1 (APBA1) anticorps
  • amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) (apba1) anticorps
  • ketopantoate reductase (apbA1) anticorps
  • 2-dehydropantoate 2-reductase (apbA1) anticorps
  • 2-dehydropantoate 2-reductase (apba1) anticorps
  • amyloid beta (A4) precursor protein-binding, family A, member 1 (apba1) anticorps
  • amyloid beta (A4) precursor protein binding, family A, member 1 (Apba1) anticorps
  • amyloid beta (A4) precursor protein-binding, family A, member 1 (Apba1) anticorps
  • 6430513E09Rik anticorps
  • APBA1 anticorps
  • D9S411E anticorps
  • Lin-10 anticorps
  • LIN10 anticorps
  • Mint anticorps
  • MINT1 anticorps
  • Urop11 anticorps
  • X11 anticorps
  • X11A anticorps
  • X11ALPHA anticorps

Protein level used designations for APBA1

amyloid beta (A4) precursor protein-binding, family A, member 1 , amyloid beta A4 precursor protein-binding, family A, member 1 , amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) , ketopantoate reductase , 2-dehydropantoate 2-reductase , Amyloid beta A4 precursor protein-binding family A member 1 , amyloid beta A4 precursor protein-binding family A member 1-like , UROP11-110 , adapter protein X11alpha , amyloid beta A4 precursor protein-binding family A member 1 , mint-1 , neuron-specific X11 protein , neuronal Munc18-1-interacting protein 1 , amyloid beta (A4) precursor protein-binding family A APBA1: amyloid beta (A4) precursor protein-binding family A member 1 (X11) , amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) , adaptor protein X11alpha , neuronal munc18-1-interacting protein 1 , phosphotyrosine-binding/-interacting domain (PTB)-bearing protein

GENE ID SPECIES
472947 Pan troglodytes
565507 Danio rerio
699838 Macaca mulatta
4247161 Ralstonia eutropha H16
4606254 Azoarcus sp. BH72
9788884 Pantoea vagans C9-1
100380423 Salmo salar
100390315 Callithrix jacchus
100439123 Pongo abelii
100483732 Ailuropoda melanoleuca
100485825 Xenopus (Silurana) tropicalis
319924 Mus musculus
83589 Rattus norvegicus
320 Homo sapiens
427246 Gallus gallus
100686233 Canis lupus familiaris
100513711 Sus scrofa
515571 Bos taurus
Fournisseurs de qualité sélectionnés pour anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Anticorps
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