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AMOTL2 belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. De plus, nous expédions Angiomotin Like 2 Protéines (4) et Angiomotin Like 2 Kits (2) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal AMOTL2 Primary Antibody pour WB - ABIN652806
Bratt, Wilson, Troyanovsky, Aase, Kessler, Van Meir, Holmgren, Meir: Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains. dans Gene 2002
Show all 2 Pubmed References
Amotl2a function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (Montrer YAP1 Anticorps) and the Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) effector Lef1 (Montrer LEF1 Anticorps).
amotL2 associates to the VE-cadherin adhesion complex where it couples adherens junctions to contractile actin fibres.
We demonstrate that amotl2 knockdown in zebrafish wild-type embryos results in embryonic dorsalization, and this effect can be antagonized by co-knockdown of the dorsal inducer beta-catenin2.
Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells
Amotl2 interacts preferentially with and facilitates translocation of the phosphorylated c-Src (Montrer SRC Anticorps), which may in turn regulate the membrane architecture. These data provide the first evidence that amotl2 is essential for cell movements in vertebrate embryos.
these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP (Montrer YAP1 Anticorps) and AKT (Montrer AKT1 Anticorps) in liver size control and cancer prevention
study reports for the first time that USP9X (Montrer USP9X Anticorps) is a deubiquitinase of Angiomotin-like 2 (AMOTL2) and that AMOTL2 mono-ubiquitination is required for YAP (Montrer YAP1 Anticorps) inhibition
mTORC2 (Montrer CRTC2 Anticorps)-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP (Montrer YAP1 Anticorps) signaling.
AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients.
Scaffold proteins angiomotin (Amot (Montrer AMOT Anticorps)) and angiomotin (Montrer AMOT Anticorps)-related AmotL1 (Montrer AMOTL1 Anticorps) and AmotL2 were recently identified as negative regulators of YAP (Montrer YAP1 Anticorps) and TAZ (Montrer TAZ Anticorps) by preventing their nuclear translocation.
These results collectively suggest that the Hippo pathway negatively regulates the actin-binding activity of Amot (Montrer AMOT Anticorps) family members through direct phosphorylation.
These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process.
AMOTL2 interacts with TAZ (Montrer TAZ Anticorps) and modulates transcriptional activity of TAZ (Montrer TAZ Anticorps).
AMOTL2 is as a novel activator of LATS2 (Montrer LATS2 Anticorps).
AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion.
Amot (Montrer AMOT Anticorps), Amotl1 (Montrer AMOTL1 Anticorps), and Amotl2 are differentially expressed in uterine cells during the peri (Montrer POSTN Anticorps)-implantation period.
Data show that MUPP1 (Montrer MPDZ Anticorps) interacts with angiomotin (Amot (Montrer AMOT Anticorps)), JEAP (Montrer AMOTL1 Anticorps)/Amot (Montrer AMOT Anticorps)-like 1 and MASCOT/Amot (Montrer AMOT Anticorps)-like 2, and that all the Amot (Montrer AMOT Anticorps)/JEAP (Montrer AMOTL1 Anticorps) family proteins also interacted with Patj (Montrer INADL Anticorps), a close relative of MUPP1 (Montrer MPDZ Anticorps).
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.
angiomotin like 1
, angiomotin-like protein 1
, angiomotin like 2
, angiomotin-like 2a
, angiomotin-like protein 1-like
, angiomotin-like protein 2-like
, Leman coiled-coil protein
, angiomotin-like protein 2