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CCBP2 encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. De plus, nous expédions CCBP2 Protéines (4) et CCBP2 Kits (3) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal CCBP2 Primary Antibody pour IHC (p), ELISA - ABIN4369828
Soler, Humphreys, Spinola, Campbell: CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. dans Blood 2003
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Human Monoclonal CCBP2 Primary Antibody pour CyTOF, FACS - ABIN4899116
Martinez de la Torre, Buracchi, Borroni, Dupor, Bonecchi, Nebuloni, Pasqualini, Doni, Lauri, Agostinis, Bulla, Cook, Haribabu, Meroni, Rukavina, Vago, Tedesco, Vecchi, Lira, Locati, Mantovani: Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6. dans Proceedings of the National Academy of Sciences of the United States of America 2007
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Data show the structural motifs in the atypical chemokine receptor 2 (ACKR2) are responsible for ligand binding, and suggest ACKR2-derived N-terminal peptides as being of potential therapeutic significance.
engagement of the ACR (Montrer ACR Anticorps) D6 by its ligands activates a beta (Montrer SUCLA2 Anticorps)-arrestin1 (Montrer ARRB1 Anticorps)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein (Montrer KPTN Anticorps) cofilin (Montrer CFL1 Anticorps) through the Rac1-PAK1 (Montrer PAK1 Anticorps)-LIMK1 (Montrer LIMK1 Anticorps) cascade.
co-expression of DARC (Montrer DARC Anticorps), D6, and CCX-CKR (Montrer CCRL1 Anticorps) significantly associated with higher survival in gastric cancer
CCL2 binding to primary adult human astrocytes is CCR2-independent and is likely to be mediated via the D6 decoy.
D6 is expressed in AMs (Montrer MAT1A Anticorps) from patients with COPD (Montrer ARCN1 Anticorps), and its expression correlates with the degree of functional impairment and markers of immune activation.
Chemokine (Montrer CCL1 Anticorps) decoy receptor D6 limits CC-chemokine (Montrer CCL1 Anticorps)-dependent pathogenic inflammation and is required for adequate cardiac remodeling after myocardial infarction.
DARC (Montrer DARC Anticorps) and D6, the most studied members of this group of molecules, are reviewed.
CCR10 (Montrer CCR10 Anticorps) is unlikely to be necessary for cutaneous homing of TH cells in the models studied here. CCR10 (Montrer CCR10 Anticorps) may instead play a role in the movement of specialized "effector" cutaneous TH cells to and/or within epidermal microenvironments.
CCR10 and its mucosal epithelial ligand CCL28 have roles in the migration of circulating IgA plasmablasts
D6 is constitutively internalized via a ligand-independent, phosphorylation-independent association with beta-arrestin.
a comprehensive model of CCL19 (Montrer CCL19 Anticorps) and CCL21 (Montrer CCL21 Anticorps) transport and gradient formation in the lymph nodes (LNs) was built; predicts that ACKR4 in LNs prevents CCL19 (Montrer CCL19 Anticorps)/CCL21 (Montrer CCL21 Anticorps) accumulation in efferent lymph, but does not control intranodal gradients; instead, it attributes the disrupted interfollicular CCL21 (Montrer CCL21 Anticorps) gradients observed in Ackr4-deficient LNs to ACKR4 loss upstream
study found that the inflammatory chemokine (Montrer CCL1 Anticorps) CCL5 (Montrer CCL5 Anticorps) is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 (Montrer CCL5 Anticorps) exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN (Montrer TBCE Anticorps)-expressed D6.
ACKR4 on stromal cells aids the egress of antigen presenting cells from mouse skin, and, during inflammation, facilitates CCR7 (Montrer CCR7 Anticorps)-dependent cell trafficking by scavenging CCL19 (Montrer CCL19 Anticorps).
The data shows a novel function for the chemokine receptor CCX-CKR (Montrer CCRL1 Anticorps) as a regulator of TGF-beta1 (Montrer TGFB1 Anticorps) expression and epithelial-mesenchymal transition in breast cancer cells.
CCRL1 (Montrer CCRL1 Anticorps) is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice.
Further examination revealed that proximity of pro-lymphangiogenic macrophages to developing lymphatic vessel surfaces is increased in ACKR2-deficient mice and reduced in CCR2-deficient mice.
stepwise acquisition of chemokine (C-C motif) receptor-like 1 (CCRL1 (Montrer CCRL1 Anticorps)) is a late determinant of cortical thymic epithelial cell differentiation
some cells, including plasmacytoid dendritic cells, can express both CCR2 (Montrer CCR2 Anticorps) and ACKR2; that Ly6C(high) monocytes have particularly strong CCL2 (Montrer CCL2 Anticorps)-scavenging potential in vitro and in vivo; and that CCR2 (Montrer CCR2 Anticorps) is a much more effective CCL2 (Montrer CCL2 Anticorps) scavenger than ACKR2.
found that lymph node fringes indeed contained physiological gradients of the chemokine (Montrer CCL1 Anticorps) CCL21 (Montrer CCL21 Anticorps), which depended on the expression of CCRL1 (Montrer CCRL1 Anticorps), the atypical receptor for the CCR7 (Montrer CCR7 Anticorps) ligands CCL19 (Montrer CCL19 Anticorps) and CCL21 (Montrer CCL21 Anticorps)
CCX-CKR (Montrer CCRL1 Anticorps) deletion increases incidence of a spontaneous Sjogren's syndrome-like pathology, suggestive of a defect in self-tolerance. CCX-CKR (Montrer CCRL1 Anticorps)(-/-) mice have fewer thymic epithelial cells per thymocyte, with defects in thymocyte distribution & frequency.
This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members\; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.
C-C chemokine receptor D6
, CC-chemokine-binding receptor JAB61
, chemokine (C-C motif) receptor 9
, chemokine (C-C) receptor 9
, chemokine binding protein 2
, chemokine receptor CCR-10
, chemokine receptor CCR-9
, chemokine receptor D6
, chemokine-binding protein 2
, chemokine-binding protein D6
, CCR10-related receptor
, C-C CKR-11
, C-C chemokine receptor type 11
, CC chemokine receptor-like 1
, CCX CKR
, chemokine (C-C motif) receptor-like 1
, chemokine (C-C) receptor-like 1
, chemokine receptor CCR11
, D6 beta-chemokine receptor