anti-Coagulation Factor VIII (F8) Anticorps

F8 encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation\; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. De plus, nous expédions Factor VIII Kits (53) et Factor VIII Protéines (32) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
F8 14069 Q06194
F8 2157 P00451
F8 302470  
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Top anti-Factor VIII Anticorps sur anticorps-enligne.fr

Showing 10 out of 342 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB Host: Rabbit <br /> Target Name: F8 <br /> Sample Tissue: 721_B Whole Cell <br /> Lane A:  Primary Antibody Lane B:  Primary Antibody + Blocking Peptide <br />Primary Antibody Concentration: 1 µg/mL Peptide Concentration: 2 µg/mL Lysate Quantity: 241 µg/laneGel Concentration: 2.12 % 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Western Blot: Factor VIII antibody (S2194) [ABIN4493381] - in extracts from HuvEc cells. Immunocytochemistry/Immunofluorescence: Factor VIII Antibody [ABIN4493381] - Factor VIII antibody was tested 1:50 in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). Image objective 40x. 0.1 mg Connectez-vous pour afficher 3 to 5 Days
451,25 €
Détails
Chien Lapin Inconjugué WB Western blot analysis of Factor VIII expression in HeLa (A), HepG2 (B) whole cell lysates. 200 μL Connectez-vous pour afficher 11 to 13 Days
464,29 €
Détails
Humain Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 8 to 11 Days
298,57 €
Détails
Humain Souris Inconjugué ELISA Detection limit for recombinant GST tagged F8 is approximately 3 ng/mL as a capture antibody. 0.1 mg Connectez-vous pour afficher 12 to 16 Days
454,76 €
Détails
Humain Lapin Inconjugué IF (p), IHC (p) Formalin-fixed and paraffin embedded human skin labeled with Anti-Factor VIII Polyclonal Antibody, Unconjugated (ABIN872493) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Connectez-vous pour afficher 9 to 12 Days
315,94 €
Détails
Chien Lapin Inconjugué IF (p), IHC (p) Formalin-fixed and paraffin embedded rat tibia tissue labeled with Anti-Factor VIII (FVIII) Polyclonal Antibody (ABIN668601) , Unconjugated at 1:300, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed : Mouse C57 cells labeled with Anti- Factor VIII (FVIII) Polyclonal Antibody (ABIN668601) , Unconjugated at 1:300, followed by conjugation to the secondary antibody was Goat Anti-Rabbit IgG, PE conjugated  at 1:200 for 40 minutes at 37 °C DAPI (5 µg/mL, blue) was used to stain the cell nuclei 100 μL Connectez-vous pour afficher 9 to 12 Days
315,94 €
Détails
Humain Lapin Inconjugué IF (cc), IF (p), IHC (p) Formalin-fixed and paraffin embedded:human colon carcinoma labeled with Anti-factor VIII(FVIII) (human) Polyclonal Antibody (ABIN728000), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded:human colon carcinoma labeled with Anti-factor VIII(FVIII)(human) Polyclonal Antibody , Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Connectez-vous pour afficher 9 to 12 Days
315,94 €
Détails
Humain Souris Inconjugué ELISA, WB   100 μL Connectez-vous pour afficher 14 to 16 Days
468,37 €
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts from HuvEc cells, using Factor VIII Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 6 to 8 Days
342,86 €
Détails

F8 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-Factor VIII Anticorps mieux référencés

  1. Human Polyclonal Factor VIII Primary Antibody pour WB - ABIN3042924 : Wu, Chen, Guo, He, Hu: Effects of transforming growth factor-?2 on myocilin expression and secretion in human primary cultured trabecular meshwork cells. dans International journal of clinical and experimental pathology 2014 (PubMed)
    Show all 15 Pubmed References

  2. Dog (Canine) Polyclonal Factor VIII Primary Antibody pour IF (p), IHC (p) - ABIN668601 : Yu, Zhang, Jiang, Wang, Zhang: Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction. dans Molecular medicine reports 2015 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal Factor VIII Primary Antibody pour ICC, IF - ABIN449338 : Zhu, Liu, Miao, Qu, Chi: Enhanced plasma factor VIII activity in mice via cysteine mutation using dual vectors. dans Science China. Life sciences 2012 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal Factor VIII Primary Antibody pour IF (p), IHC (p) - ABIN872493 : Tang, Liu, Dong, Li, Li, Hou, Zheng, Lin, Ren: Protective Effect of Kaempferol on LPS plus ATP-Induced Inflammatory Response in Cardiac Fibroblasts. dans Inflammation 2014 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal Factor VIII Primary Antibody pour ELISA, WB - ABIN969123 : Shovlin, Sulaiman, Govani, Jackson, Begbie: Elevated factor VIII in hereditary haemorrhagic telangiectasia (HHT): association with venous thromboembolism. dans Thrombosis and haemostasis 2007 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal Factor VIII Primary Antibody pour IF (cc), IF (p) - ABIN728000 : Zhou, Zhu, Zou, Wang: Changes in number and biological function of endothelial progenitor cells in hypertension disorder complicating pregnancy. dans Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2008 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal Factor VIII Primary Antibody pour ELISA, WB - ABIN966113 : Venceslá, Corral-Rodríguez, Baena, Cornet, Domènech, Baiget, Fuentes-Prior, Tizzano: Identification of 31 novel mutations in the F8 gene in Spanish hemophilia A patients: structural analysis of 20 missense mutations suggests new intermolecular binding sites. dans Blood 2008 (PubMed)
    Show all 2 Pubmed References

  8. Dog (Canine) Polyclonal Factor VIII Primary Antibody pour IHC, ELISA - ABIN1582291 : Shen, Li, Chung, Gillies: Retinal vascular changes after glial disruption in rats. dans Journal of neuroscience research 2010 (PubMed)

Plus d’anticorps contre Factor VIII partenaires d’interaction

Zebrafish Coagulation Factor VIII (F8) interaction partners

  1. gene is flanked by factor VII (Montrer TH Anticorps) and factor X genes; gene encodes a protein homologous to factor VII (Montrer TH Anticorps), but lacks critical residues for factor VII (Montrer TH Anticorps) activity; functions as an inhibitor of blood coagulation in biochemical assays using zebrafish or human plasmas

Mouse (Murine) Coagulation Factor VIII (F8) interaction partners

  1. Cytokine release was quantified from FVIII(-/-) splenocytes restimulated with FVIII in the absence or presence of different anti-FcgammaRIIB (CD32) Antibodies (anti-CD32 mAbs) over 6 days.

  2. results revealed localized vascular expression of FVIII and von Willebrand factor (Montrer VWF Anticorps) and identified lymphatic endothelial cell as a major cellular source of FVIII in extrahepatic tissues.

  3. the results indicate that residues in the C1 and/or C2 domains of factor VIII are implicated in immunogenic factor VIII uptake, at least in vitro Conversely, in vivo, the binding to endogenous von Willebrand factor (Montrer VWF Anticorps) masks the reducing effect of mutations in the C domains on factor VIII immunogenicity.

  4. data demonstrate that infusion of platelets containing FVIII triggers neither primary nor memory anti-FVIII immune response in FVIII(null) mice

  5. Both platelet-VWF (Montrer VWF Anticorps) and plasma-VWF (Montrer VWF Anticorps) are required for optimal platelet-derived FVIII gene therapy for hemophilia A in the presence of inhibitors.

  6. These data support the investigation of FVIII orthologs as treatment modalities in both the congenital and acquired FVIII inhibitor settings.

  7. Activatable bioengineered FIX molecules with FVIII-independent activity might be a promising tool for improving hemophilia A treatment, especially for patients with inhibitors.

  8. This study demonstrated that FVIIIa interacts with Low-density lipoprotein receptor-related protein 1 (Montrer LRP1 Anticorps) cluster III.

  9. a fragment containing only approximately 20% of the VWF (Montrer VWF Anticorps) sequence is sufficient to support FVIII stability in vivo

  10. Endothelial cells from multiple, but not all, tissues contribute to the plasma FVIII pool in the mouse.

Human Coagulation Factor VIII (F8) interaction partners

  1. A coagulation initiating pathway is revealed in which the TF-FVIIa-nascent FXa (Montrer F10 Anticorps) complex activates FVIII apart from thrombin (Montrer F2 Anticorps) feedback.

  2. An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII by thrombin (Montrer F2 Anticorps) has been presented.

  3. Of special importance is the sequential formation of disulfide bonds with different functions in structural support of VWF (Montrer VWF Anticorps) multimers, which are packaged, stored and further processed after secretion. Here, all these processes are being reviewed in detail including background information on the occurring biochemical reactions. [review]

  4. The FVIII C1 domain contributes significantly to the immune response against FVIII in acquired and congenital hemophilia inhibitor patients.

  5. the existing epidemiologic investigations with an overview of the range of possible biochemical and immunologic mechanisms that may contribute to the different immune outcomes observed with plasma-derived and recombinant FVIII products.

  6. discuss potential mechanisms through which these intronic SNPs regulate ST3GAL4 (Montrer ST3GAL4 Anticorps) biosynthesis and the activity that affects VWF (Montrer VWF Anticorps) and FVIII

  7. the half-life of VWF (Montrer VWF Anticorps) ( approximately 15 hours) appears to be the limiting factor that has confounded attempts to extend the half-life of rFVIII.

  8. results revealed localized vascular expression of FVIII and von Willebrand factor (Montrer VWF Anticorps) and identified lymphatic endothelial cell as a major cellular source of FVIII in extrahepatic tissues.

  9. the results indicate that residues in the C1 and/or C2 domains of factor VIII are implicated in immunogenic factor VIII uptake, at least in vitro Conversely, in vivo, the binding to endogenous von Willebrand factor (Montrer VWF Anticorps) masks the reducing effect of mutations in the C domains on factor VIII immunogenicity.

  10. Our finding that the C2-domain of FVIII can be replaced by that of FV without compromising FVIII activity may have translational implications.

Pig (Porcine) Coagulation Factor VIII (F8) interaction partners

  1. It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.

  2. thrombin (Montrer F2 Anticorps) stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (Montrer UGDH Anticorps) and by receptor-mediated up-regulation of factor XIII (Montrer UGDH Anticorps) synthesis

  3. cupredoxin-like A1 subdomains in fVIII contain inter-species differences that are a result of selective pressure on the dissociation rate constant

Cow (Bovine) Coagulation Factor VIII (F8) interaction partners

  1. Factor VIIIc (Montrer COX7A2 Anticorps) is responsible for tissue invasion during tumor progression.

Factor VIII (F8) profil antigène

Profil protéine

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation\; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Gene names and symbols associated with F8

  • coagulation factor VIIi (f7i) anticorps
  • coagulation factor VIII (F8) anticorps
  • coagulation factor VIII, procoagulant component (F8) anticorps
  • AHF anticorps
  • Cf-8 anticorps
  • Cf8 anticorps
  • DXS1253E anticorps
  • F8B anticorps
  • F8C anticorps
  • fb61d02 anticorps
  • FVIII anticorps
  • HEMA anticorps
  • wu:fb61d02 anticorps

Protein level used designations for F8

Factor VIII , procoagulant component , antihemophilic factor , coagulation factor VIII , coagulation factor VIIIc , factor VIII F8B , coagulation factor VIII, procoagulant component (hemophilia A) , factor VIII , coagulation co-factor

GENE ID SPECIES
282671 Danio rerio
14069 Mus musculus
2157 Homo sapiens
397339 Sus scrofa
403875 Canis lupus familiaris
100271720 Bos taurus
100303761 Oryctolagus cuniculus
302470 Rattus norvegicus
100359363 Ovis aries
422199 Gallus gallus
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