anti-Muscleblind-Like 2 (Drosophila) (MBNL2) Anticorps

MBNL2 is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. De plus, nous expédions MBNL2 Protéines (6) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MBNL2 105559 Q8C181
MBNL2 10150 Q5VZF2
MBNL2 680445 F2Z3T4
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Top anti-MBNL2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 31 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué EIA, FACS, IHC (p), WB Flow cytometric analysis of Hela cells using MBNL2 Antibody (C-term) Cat.-No AP52623PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue reacted with MBNL2 Antibody (C-term) followed which was peroxidase conjugated to the secondary antibody and followed by AB staining. 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-MBNL2 Antibody Titration: 0.2-1 ug/mlPositive Control: Human brain 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Lapin Inconjugué FACS, IHC (p), WB MBNL2 Antibody (C-term)  western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MBNL2 antibody detected the MBNL2 protein (arrow). MBNL2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MBNL2 Antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Roussette (Chauve-souris) Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 11 to 14 Days
653,02 €
Détails
Humain Lapin Inconjugué ELISA, WB 50 μg Connectez-vous pour afficher 6 to 8 Days
459,65 €
Détails
Humain Lapin Inconjugué IHC, IHC (p) Immunohistochemistry-Paraffin: MBNL2 Antibody [NBP2-43638] - Analysis of human colon carcinoma. MBNL2 antibody dilution: 1:500. Immunohistochemistry-Paraffin: MBNL2 Antibody [NBP2-43638] - Analysis of mouse liver. MBNL2 antibody dilution: 1:500. 0.1 mL Connectez-vous pour afficher 4 to 7 Days
426,25 €
Détails
Humain Souris Inconjugué IF, ELISA Detection limit for recombinant GST tagged MBNL2 is 0.03 ng/ml as a capture antibody. Immunofluorescence of monoclonal antibody to MBNL2 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Connectez-vous pour afficher 7 to 8 Days
369,60 €
Détails
Humain Lapin Inconjugué ICC, IF Immunocytochemistry/Immunofluorescence: MBNL2 Antibody  - Staining of human cell line SK-MEL-30 shows localization to nucleoplasm. 100 μL Connectez-vous pour afficher 6 to 9 Days
418,75 €
Détails
Humain Lapin Inconjugué WB Western Blot: MBNL2 Antibody [NBP1-79451] - Human Fetal Heart, Antibody Dilution: 1.0 ug/ml. Western Blot: MBNL2 Antibody [NBP1-79451] - Human Brain lysate, concentration 0.2-1 ug/ml. 100 μL Connectez-vous pour afficher 4 to 7 Days
426,25 €
Détails
Humain Lapin Inconjugué WB MBNL2 antibody used at 0.2-1 ug/ml to detect target protein. 50 μg Connectez-vous pour afficher 10 to 13 Days
460,89 €
Détails

MBNL2 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
Mouse (Murine) ,


Human , , ,
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Rat (Rattus)


anti-MBNL2 Anticorps mieux référencés

  1. Human Polyclonal MBNL2 Primary Antibody pour EIA, FACS - ABIN953337 : Adereth, Dammai, Kose, Li, Hsu: RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1. dans Nature cell biology 2005 (PubMed)
    Show all 3 references for 953337

Plus d’anticorps contre MBNL2 partenaires d’interaction

Mouse (Murine) Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. Depletion of Mbnl1 (Montrer MBNL1 Anticorps) and/or Mbnl2 reduced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites

  2. Sense DMPK (Montrer DMPK Anticorps) RNA foci clearly co-localize with MBNL1 (Montrer MBNL1 Anticorps) and MBNL2 proteins and accumulate in myotonic dystrophy 1 tissues during development.

  3. depletion of Mbnl (Montrer MBNL1 Anticorps) proteins in mouse embryo fibroblasts leads to misregulation of thousands of alternative polyadenylation events.

  4. consistent with a central and negative regulatory role for MBNL (Montrer MBNL1 Anticorps) proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  5. This analysis identified several hundred splicing events whose regulation depended on Mbnl (Montrer MBNL1 Anticorps) function in a pattern indicating functional interchangeability between Mbnl1 (Montrer MBNL1 Anticorps) and Mbnl2.

  6. We propose that major pathological features of the myotonic dystrophy brain result from disruption of the MBNL2-mediated developmental splicing program

  7. Conserved developmental stage- and tissue-specific alternative splicing of MBNL (Montrer MBNL1 Anticorps) transcripts is an important mechanism by which MBNL (Montrer MBNL1 Anticorps) activity is regulated during embryonic development.

  8. The authors propose that expanded CTG DNA repeats cause two separate effects: loss of Mbnl1 (Montrer MBNL1 Anticorps) function (disrupting splicing) and loss of another function that disrupts extracellular matrix mRNA regulation, possibly mediated by Mbnl2.

  9. MBNL2 contribute to the pathogenesis of myotonic dystrophy.

Zebrafish Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. MBNL2 in splicing regulation of specific transcripts, which, when altered, contributes to the myotonic dystrophy phenotype.

Human Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. Sense DMPK (Montrer DMPK Anticorps) RNA foci clearly co-localize with MBNL1 (Montrer MBNL1 Anticorps) and MBNL2 proteins and accumulate in myotonic dystrophy 1 tissues during development.

  2. both MBNL1 and MBNL2 are involved in the regulation of Tau exon 2 splicing and the mis-splicing of Tau in DM1 is due to the combined inactivation of both

  3. consistent with a central and negative regulatory role for MBNL (Montrer MBNL1 Anticorps) proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  4. We propose that major pathological features of the myotonic dystrophy brain result from disruption of the MBNL2-mediated developmental splicing program

  5. MBNL (Montrer MBNL1 Anticorps) proteins promote opposite splicing patterns for cardiac troponin T (Montrer TNNT2 Anticorps) and insulin receptor (Montrer INSR Anticorps) alternative exons

  6. MBNL1 (Montrer MBNL1 Anticorps) and MBNL2 always co-distributed. Functional differences between MBNL1 (Montrer MBNL1 Anticorps) and MBNL2 have not yet been found

  7. solution structures of both tandem zinc finger (TZF (Montrer Znf318 Anticorps)) motifs, TZF12 (comprising ZF1 (Montrer PRMT1 Anticorps) and ZF2 (Montrer ZNF274 Anticorps)) and TZF34 (ZF3 and ZF4), in MBNL2

MBNL2 profil antigène

Profil protéine

This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined.

Gene names and symbols associated with MBNL2

  • muscleblind-like 2 (Mbnl2) anticorps
  • muscleblind-like 2 (Drosophila) (mbnl2) anticorps
  • muscleblind-like 2 (Drosophila) (MBNL2) anticorps
  • muscleblind-like splicing regulator 2 (MBNL2) anticorps
  • muscleblind-like splicing regulator 2 (Mbnl2) anticorps
  • 1110002M11Rik anticorps
  • AI047808 anticorps
  • AI837313 anticorps
  • AI849185 anticorps
  • AL118326 anticorps
  • MBLL anticorps
  • MBLL39 anticorps
  • mKIAA4072 anticorps
  • PRO2032 anticorps
  • R75232 anticorps
  • wu:fj89c04 anticorps

Protein level used designations for MBNL2

muscleblind-like protein 2 , fj89c04 , muscleblind-like 2 , muscleblind-like protein 1 , muscleblind-like protein-like 39

GENE ID SPECIES
105559 Mus musculus
560384 Danio rerio
418784 Gallus gallus
527679 Bos taurus
10150 Homo sapiens
612815 Canis lupus familiaris
680445 Rattus norvegicus
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