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SREBF2 encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. De plus, nous expédions Sterol Regulatory Element Binding Transcription Factor 2 Protéines (10) et Sterol Regulatory Element Binding Transcription Factor 2 Kits (6) et beaucoup plus de produits pour cette protéine.
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Chicken Monoclonal SREBF2 Primary Antibody pour ELISA, GS - ABIN4355936
Janowski, Shan, Russell: The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols. dans The Journal of biological chemistry 2001
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Human Polyclonal SREBF2 Primary Antibody pour ICC, IF - ABIN261631
Huster, Purnat, Burkhead, Ralle, Fiehn, Stuckert, Olson, Teupser, Lutsenko: High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease. dans The Journal of biological chemistry 2007
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Human Polyclonal SREBF2 Primary Antibody pour EIA, IF - ABIN954950
Gerin, Clerbaux, Haumont, Lanthier, Das, Burant, Leclercq, MacDougald, Bommer: Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. dans The Journal of biological chemistry 2010
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Human Monoclonal SREBF2 Primary Antibody pour IP, WB - ABIN967564
Hua, Sakai, Ho, Goldstein, Brown: Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection. dans The Journal of biological chemistry 1996
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Human Polyclonal SREBF2 Primary Antibody pour IF, IHC (p) - ABIN654630
Marquart, Allen, Ory, Baldán: miR-33 links SREBP-2 induction to repression of sterol transporters. dans Proceedings of the National Academy of Sciences of the United States of America 2010
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Human Monoclonal SREBF2 Primary Antibody pour ChIP, WB - ABIN2668815
Daniëls, Smans, Royaux, Chypre, Swinnen, Zaidi: Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment. dans PLoS ONE 2014
Chicken Polyclonal SREBF2 Primary Antibody pour WB - ABIN2792226
Zeng, Liao, Liu, Lee, Zhu, Wang, Stemerman, Zhu, Shyy: Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. dans The Journal of biological chemistry 2004
SREBP-2 is critical for survival and limb patterning during development
Identify a novel signaling pathway in hepatocytes triggered by ligand-activated p75NTR (Montrer NGFR Anticorps) that via p38 MAPK (Montrer MAPK14 Anticorps) and caspase-3 (Montrer CASP3 Anticorps) mediate the activation of SREBP2. This pathway may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF (Montrer NGFB Anticorps) and pro-NGF (Montrer NGFB Anticorps).
This study reveals SHP (Montrer LAMC1 Anticorps) as a global transcriptional partner of SREBP-2 in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (Montrer FGF19 Anticorps).
activation of the sterol regulatory element binding protein-2 (SREBP2) was found to be downstream of ER stress, and this activation was affirmed to account for the intracellular accumulation of cholesterol using RNAi technique
ITCH modulates SIRT6 (Montrer SIRT6 Anticorps) and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE (Montrer APOE Anticorps) null mice
SREBP2-induced miR (Montrer MLXIP Anticorps)-92a targets key molecules in endothelial homeostasis, including sirtuin 1 (Montrer SIRT1 Anticorps), Kruppel-like factor 2, and Kruppel-like factor 4 (Montrer KLF4 Anticorps), leading to NOD-like receptor family pyrin domain-containing 3 inflammasome activation and endothelial nitric oxide synthase (Montrer NOS3 Anticorps) inhibition.
The cholesterol-lowering effects of FGF21 (Montrer FGF21 Anticorps) are abrogated by hepatic expression of sterol regulatory element-binding protein-2.
Data indicate that Leishmania exploits macrophage cholesterol-dependent sterol regulatory element binding factor 2 (SREBP2) circuit to facilitate its entry and survival within the host.
Demonstrate that the activation of FXR (Montrer NR1H4 Anticorps) uncouples the expression of nuclear SREBP-2 and miR (Montrer MLXIP Anticorps)-33, and the regulation of their respective target genes.
the cardiac sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-coenzyme A reductase (Montrer HMGCR Anticorps) pathway being upregulated in MMP-2 (Montrer MMP2 Anticorps) deficiency.
Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells.
Data show that mutant p53 protein (Montrer TP53 Anticorps) activates the sterol regulatory element-binding proteins SREBP-1 (Montrer SREBF1 Anticorps) and SREBP-2-mediated signaling pathways in prostate cancer (PCa (Montrer FLVCR1 Anticorps)) cells.
The connections of EGFR (Montrer EGFR Anticorps) and ERBB4 (Montrer ERBB4 Anticorps) signaling with SREBP-2-regulated cholesterol metabolism are likely to be important in ERBB (Montrer EGFR Anticorps)-regulated developmental processes and may contribute to metabolic remodeling in ERBB (Montrer EGFR Anticorps)-driven cancers.
Akt1 (Montrer AKT1 Anticorps) and Akt2 (Montrer AKT2 Anticorps) activated both SREBP-1 (Montrer SREBF1 Anticorps) and SREBP-2, whereas Akt3 (Montrer AKT3 Anticorps) upregulated SREBP-1 (Montrer SREBF1 Anticorps) to enhance hepatitis C virus translation.
knockdown of endogenous SREBP2 in HepG2 cells lowered ACSL1 (Montrer Acsl1 Anticorps) mRNA and protein levels.
Data suggest that Hepacivirus (HCV) activates hepatocyte NLRP3 (Montrer NLRP3 Anticorps) inflammasomes, induces lipogenic enzymes/lipid droplet formation, and up-regulates transport of SREBF1 (Montrer SREBF1 Anticorps)/SREBF2/SCAP (Montrer SH2D2A Anticorps) from ER to Golgi where SREBPs undergo proteolytic activation by S1P (Montrer MBTPS1 Anticorps)/S2P (Montrer MBTPS2 Anticorps).
Data suggest lysophosphatidylcholine (LPC (Montrer PCSK7 Anticorps)) up-regulates SREBP-2 and cholesterol efflux in vascular endothelium; 25-hydroxycholesterol (25-HC) inhibits these effects of LPC (Montrer PCSK7 Anticorps); both LPC (Montrer PCSK7 Anticorps) and 25-HC up-regulate release of interleukin-6 (Montrer IL6 Anticorps) and interleukin-8 (Montrer IL8 Anticorps).
the results of the present study showed that luteolin modulates HMGCR (Montrer HMGCR Anticorps) transcription by decreasing the expression and nuclear translocation of SREBP-2.
performed a detailed promoter/enhancer analysis of ELOVL5 (Montrer ELOVL5 Anticorps) gene, and identified two new SREBP binding sites, one in the 10 kb upstream region and one in the exon 1
dysregulation of SIRT1 (Montrer SIRT1 Anticorps)-AMPK (Montrer PRKAA1 Anticorps)-SREBP and stimulation of NLRP3 (Montrer NLRP3 Anticorps) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis
KLF13 (Montrer KLF13 Anticorps) and SREBP-Sp1 (Montrer SP1 Anticorps) activation interact to regulate low density lipoprotein receptor (Montrer LDLR Anticorps) promoter function
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
sterol regulatory element binding transcription factor 2
, sterol regulatory element-binding protein 2-like
, sterol regulatory element binding protein 2
, sterol regulatory element-binding protein 2
, sterol regulatory element-binding transcription factor 2
, class D basic helix-loop-helix protein 2
, sterol regulatory element binding factor 2