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SREBF2 encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. De plus, nous expédions Sterol Regulatory Element Binding Transcription Factor 2 Protéines (10) et Sterol Regulatory Element Binding Transcription Factor 2 Kits (6) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 65 products:
Human Polyclonal SREBF2 Primary Antibody pour EIA, IF - ABIN954950
Gerin, Clerbaux, Haumont, Lanthier, Das, Burant, Leclercq, MacDougald, Bommer: Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. dans The Journal of biological chemistry 2010
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Human Monoclonal SREBF2 Primary Antibody pour IP, WB - ABIN967564
Hua, Sakai, Ho, Goldstein, Brown: Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection. dans The Journal of biological chemistry 1996
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Human Polyclonal SREBF2 Primary Antibody pour IF, IHC (p) - ABIN654630
Marquart, Allen, Ory, Baldán: miR-33 links SREBP-2 induction to repression of sterol transporters. dans Proceedings of the National Academy of Sciences of the United States of America 2010
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Human Monoclonal SREBF2 Primary Antibody pour ChIP, WB - ABIN2668815
Daniëls, Smans, Royaux, Chypre, Swinnen, Zaidi: Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment. dans PLoS ONE 2014
Chicken Polyclonal SREBF2 Primary Antibody pour WB - ABIN2792226
Zeng, Liao, Liu, Lee, Zhu, Wang, Stemerman, Zhu, Shyy: Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. dans The Journal of biological chemistry 2004
This study reveals SHP (Montrer LAMC1 Anticorps) as a global transcriptional partner of SREBP-2 in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (Montrer FGF19 Anticorps).
activation of the sterol regulatory element binding protein-2 (SREBP2) was found to be downstream of ER stress, and this activation was affirmed to account for the intracellular accumulation of cholesterol using RNAi technique
ITCH modulates SIRT6 (Montrer SIRT6 Anticorps) and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE (Montrer APOE Anticorps) null mice
SREBP2-induced miR-92a targets k (Montrer MLXIP Anticorps)ey molecules in endothelial homeostasis, including sirtuin 1, Kruppel-like factor 2, and Kruppel-like factor 4, leading to NOD-like receptor family pyrin domain-containing 3 inflammasome activation and endothelial nitric oxide synthase inhibition.
The cholesterol-lowering effects of FGF21 (Montrer FGF21 Anticorps) are abrogated by hepatic expression of sterol regulatory element-binding protein-2.
Data indicate that Leishmania exploits macrophage cholesterol-dependent sterol regulatory element binding factor 2 (SREBP2) circuit to facilitate its entry and survival within the host.
Demonstrate that the activation of FXR (Montrer NR1H4 Anticorps) uncouples the expression of nuclear SREBP-2 and miR (Montrer MLXIP Anticorps)-33, and the regulation of their respective target genes.
the cardiac sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-coenzyme A reductase (Montrer HMGCR Anticorps) pathway being upregulated in MMP-2 (Montrer MMP2 Anticorps) deficiency.
activation of intestinal SREBP2 alone seems to be sufficient to increase plasma cholesterol
Hepatic insulin receptor (Montrer INSR Anticorps) knockout mice manifest decreased nuclear SREBP-2 protein, decreased cholesterologenic gene expression, and decreased cholesterol synthesis.
Akt1 (Montrer AKT1 Anticorps) and Akt2 (Montrer AKT2 Anticorps) activated both SREBP-1 (Montrer SREBF1 Anticorps) and SREBP-2, whereas Akt3 (Montrer AKT3 Anticorps) upregulated SREBP-1 (Montrer SREBF1 Anticorps) to enhance hepatitis C virus translation.
knockdown of endogenous SREBP2 in HepG2 cells lowered ACSL1 (Montrer Acsl1 Anticorps) mRNA and protein levels.
Data suggest that Hepacivirus (HCV) activates hepatocyte NLRP3 (Montrer NLRP3 Anticorps) inflammasomes, induces lipogenic enzymes/lipid droplet formation, and up-regulates transport of SREBF1 (Montrer SREBF1 Anticorps)/SREBF2/SCAP (Montrer SH2D2A Anticorps) from ER to Golgi where SREBPs undergo proteolytic activation by S1P (Montrer MBTPS1 Anticorps)/S2P (Montrer MBTPS2 Anticorps).
Data suggest lysophosphatidylcholine (LPC (Montrer PCSK7 Anticorps)) up-regulates SREBP-2 and cholesterol efflux in vascular endothelium; 25-hydroxycholesterol (25-HC) inhibits these effects of LPC (Montrer PCSK7 Anticorps); both LPC (Montrer PCSK7 Anticorps) and 25-HC up-regulate release of interleukin-6 (Montrer IL6 Anticorps) and interleukin-8 (Montrer IL8 Anticorps).
the results of the present study showed that luteolin modulates HMGCR (Montrer HMGCR Anticorps) transcription by decreasing the expression and nuclear translocation of SREBP-2.
performed a detailed promoter/enhancer analysis of ELOVL5 (Montrer ELOVL5 Anticorps) gene, and identified two new SREBP binding sites, one in the 10 kb upstream region and one in the exon 1
HCV core protein disturbs the cholesterol homeostasis in HepG2 cells via the SREBP2 pathway; miR-185-5p is involved in the regulation of SREBP2 by the core protein.
the 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR (Montrer ATIC Anticorps))-induced activation of AMPK (Montrer PRKAA1 Anticorps) directly inhibited the expression of SREBP-2 and HMGCR (Montrer HMGCR Anticorps) and HMGCS (Montrer HMGCS1 Anticorps), and suppressed the TSH-stimulated up-regulation of SREBP-2 in HepG2 cells.
Methyl protodioscin increases ABCA1 (Montrer ABCA1 Anticorps) expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levels.
Suggest important role for SREBP-2 in regulation of lipid and glucose metabolism in hypertensive rats.
dysregulation of SIRT1 (Montrer SIRT1 Anticorps)-AMPK (Montrer PRKAA1 Anticorps)-SREBP and stimulation of NLRP3 (Montrer NLRP3 Anticorps) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis
KLF13 (Montrer KLF13 Anticorps) and SREBP-Sp1 (Montrer SP1 Anticorps) activation interact to regulate low density lipoprotein receptor (Montrer LDLR Anticorps) promoter function
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
sterol regulatory element binding transcription factor 2
, sterol regulatory element-binding protein 2-like
, sterol regulatory element binding protein 2
, sterol regulatory element-binding protein 2
, sterol regulatory element-binding transcription factor 2
, class D basic helix-loop-helix protein 2
, sterol regulatory element binding factor 2