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The protein encoded by TCF12 is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. De plus, nous expédions TCF12 Protéines (7) et beaucoup plus de produits pour cette protéine.
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Cow (Bovine) Polyclonal TCF12 Primary Antibody pour WB - ABIN2780487
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. dans Diagnostic microbiology and infectious disease 2006
Show all 2 Pubmed References
Heb expression is regulated by Med19 (Montrer MED19 Anticorps) in breast cancer cells.
enforced expression of transcription factor 12 suppressed cell proliferation, migration, and invasion in vitro and inhibited tumor growth in vivo. In conclusion, transcription factor 12 protein may be a novel molecule which plays a critical role in prostate cancer progression and patients' prognosis, suggesting it might be a promising therapeutic target for prostate cancer therapy
HEB may be involved in GBM cell proliferation, as HEB silencing reduced proliferation in cells cultured as monolayers or neurospheres. Furthermore, the results suggested a potential role for HEB in the maintenance of GBM stem cells, as HEB silencing affected the differentiation capacity of cells.
Two novel translocations leading to the inactivation of RUNX1 (Montrer RUNX1 Anticorps) and its partners SIN3A (Montrer SIN3A Anticorps) and TCF12 in myeloid leukemia (Montrer BCL11A Anticorps).
Studies suggest that transcription factor 12 (TCF12) should be included in level 2 genetic testing.
show that these mutations compromise TCF12 transcriptional activity and are associated with a more aggressive tumour type
several familial cases of coronal synostosis associated with mutations in TCF12
In t(8;21) leukemia cells, the two E proteins, HEB and E2A (Montrer TCF3 Anticorps), function as components of the stable AML1 (Montrer RUNX1 Anticorps)-ETO (Montrer RUNX1T1 Anticorps)-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.
haploinsufficiency of TCF12 causes coronal synostosis in humans and that severe bilateral coronal synostosis occ (Montrer TWIST1 Anticorps)urs in mice with 50% of the wild-type dosage of both the T (Montrer TWIST1 Anticorps)cf12 and Twist1 genes highlights the key role of TCF12 acting with TWIST1.
the CD91 (Montrer LRP1 Anticorps)/IKK (Montrer CHUK Anticorps)/NF-kappaB (Montrer NFKB1 Anticorps) signaling cascade is involved in secreted HSP90alpha (Montrer HSP90AA2 Anticorps)-induced TCF12 expression, leading to E-cadherin (Montrer CDH1 Anticorps) down-regulation and enhanced CRC (Montrer CALR Anticorps) cell migration/invasion
we identified transcription factor TCF12 as a new target of miR (Montrer MLXIP Anticorps)-211 in oral squamous cell carcinoma
HEB (Montrer FREM1 Anticorps) is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells
severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 and Twist1 (Montrer TWIST1 Anticorps) genes highlights the key role of TCF12 acting with TWIST1 (Montrer TWIST1 Anticorps) in the normal development of the coronal sutures
Deficiency in the E proteins, E2A (Montrer TCF3 Anticorps) and HEB (Montrer FREM1 Anticorps), led to increased frequency of terminally differentiated effector KLRG1 (Montrer KLRG1 Anticorps)(hi) CD8 (Montrer CD8A Anticorps)(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.
Deletion of HEB (Montrer FREM1 Anticorps) and E2A (Montrer TCF3 Anticorps) in DP thymocytes specifically blocked the development of CD4 (Montrer CD4 Anticorps)(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 (Montrer ID3 Anticorps) allowed CD4 (Montrer CD4 Anticorps)(+) T cell development but blocked CD8 (Montrer CD8A Anticorps)(+) lineage development.
the earliest event in B-cell specification involves the induction of FOXO1 (Montrer FOXO1 Anticorps) expression and requires the combined activities of E2A (Montrer TCF3 Anticorps) and HEB (Montrer FREM1 Anticorps)
These results showed a new set of interactions between HEB (Montrer FREM1 Anticorps), Notch1 (Montrer NOTCH1 Anticorps), and GATA3 (Montrer GATA3 Anticorps) that regulate the T-cell fate choice in developing thymocytes.
Developmental progression of fetal HEB (Montrer FREM1 Anticorps)(-/-) precursors to the pre-T-cell stage is restored by HEBAlt.
HEB (Montrer FREM1 Anticorps) is a specific and essential factor in T-cell development and in the generation of the iNKT cell lineage.
the dosage of HEB (Montrer FREM1 Anticorps) determines pT alpha (Montrer PTCRA Anticorps) gene expression in immature T cells
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
transcription factor 12
, transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)
, DNA-binding protein HTF4
, E-box-binding protein
, class B basic helix-loop-helix protein 20
, helix-loop-helix transcription factor 4
, transcription factor HTF-4
, class A helix-loop-helix transcription factor ME1
, SCBP alpha
, salivary-specific cAMP response element-binding protein alpha
, basic helix-loop-helix protein
, class A helix-loop-helix transcription factor GE1