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anti-Treacher Collins-Franceschetti Syndrome 1 (TCOF1) Anticorps

TCOF1 encodes a nucleolar protein with a LIS1 homology domain. De plus, nous expédions TCOF1 Protéines (4) et TCOF1 Kits (3) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
Anti-Rat TCOF1 TCOF1 291571  
TCOF1 21453 O08784
TCOF1 6949 Q13428
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Top anti-TCOF1 Anticorps sur

Showing 10 out of 35 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué IHC, ELISA, WB Western blot analysis of extracts from Jurkat/293/HeLa cells, using TCOF1 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TCOF1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 6 to 8 Days
342,86 €
Humain Souris Inconjugué WB Western Blot analysis of TCOF1 expression in transfected 293T cell line by TCOF1 monoclonal antibody (M02), clone 8H3. Lane 1: TCOF1 transfected lysate(152.104 KDa). Lane 2: Non-transfected lysate. 0.1 mg Connectez-vous pour afficher 12 to 16 Days
454,76 €
Humain Lapin Inconjugué ChIP, IC, IF, IHC, WB Immunofluorescent analysis of TCOF1 staining in HEK293T cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of TCOF1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Connectez-vous pour afficher 7 to 8 Days
464,29 €
Humain Lapin Inconjugué EIA, IHC (p), WB Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Western blot analysis of extracts from Jurkat/293/HeLa cells, using TCOF1 Antibody . The lane on the right is treated with the synthesized peptide. 50 μg Connectez-vous pour afficher 8 to 10 Days
517,00 €
Xenopus laevis Souris Inconjugué IHC (fro), IF, WB   5 mL Connectez-vous pour afficher 8 to 10 Days
264,00 €
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p)   0.1 mL Connectez-vous pour afficher 6 to 9 Days
418,75 €
Humain Lapin Inconjugué IHC (p), ELISA, WB 50 μL Connectez-vous pour afficher 11 to 14 Days
501,70 €
Humain Lapin Inconjugué IHC, WB 100 μL Connectez-vous pour afficher 12 Days
261,90 €
Humain Lapin Inconjugué ELISA, IF, IHC, WB   100 μL Connectez-vous pour afficher 13 Days
154,33 €
Humain Lapin Inconjugué IP Immunoprecipitation of TCOF1 transfected lysate using anti-TCOF1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with TCOF1 MaxPab mouse polyclonal antibody (B01) . 100 μL Connectez-vous pour afficher 8 to 9 Days
358,40 €

TCOF1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité
Mouse (Murine)

Human , ,
, ,

anti-TCOF1 Anticorps mieux référencés

  1. Xenopus laevis Monoclonal TCOF1 Primary Antibody pour IHC (fro), IF - ABIN126712 : Derenzini, Romagnoli, Mingazzini, Marinozzi: Interphasic nucleolar organizer region distribution as a diagnostic parameter to differentiate benign from malignant epithelial tumors of human intestine. dans Virchows Archiv. B, Cell pathology including molecular pathology 1988 (PubMed)
    Show all 3 references for ABIN126712

  2. Human Polyclonal TCOF1 Primary Antibody pour IHC, ELISA - ABIN1533867 : So, Gonzales, Henning, Dixon, Dixon, Valdez: Another face of the Treacher Collins syndrome (TCOF1) gene: identification of additional exons. dans Gene 2004 (PubMed)

  3. Human Polyclonal TCOF1 Primary Antibody pour ICC, IF - ABIN4362220 : Larsen, Hari, Clapperton, Gwerder, Gutsche, Altmeyer, Jungmichel, Toledo, Fink, Rask, Grøfte, Lukas, Nielsen, Smerdon, Lukas, Stucki: The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage. dans Nature cell biology 2014 (PubMed)

Plus d’anticorps contre TCOF1 partenaires d’interaction

Mouse (Murine) Treacher Collins-Franceschetti Syndrome 1 (TCOF1) interaction partners

  1. Role of Tcof1 in normal embryonic development, the correlation between genetic and environmental factors on the severity of craniofacial abnormalities, and the prospect for prenatal prevention of craniofacial anomalies. [review]

  2. Tcof1 acts as a modifier of Pax3 (Montrer PAX3 Anticorps) during enteric nervous system development.

  3. identified Tcof1 as an important regulator of vagal neural crest cells (NCC (Montrer SLC12A3 Anticorps)) development and enteric nervous system formation; Tcof1 loss-of-function results in a deficiency of vagal NCC (Montrer SLC12A3 Anticorps) and their delayed colonization of the gut (Montrer GUSB Anticorps) during early embryogenesis, which mimics the early stages of Hirschsprung's disease

  4. our research has therefore identified Treacle and as novel in vivo regulators of spindle fidelity, mitotic progression, and proliferation in the maintenance and localization of neural progenitor cells.

  5. Loss-of-function mutation in Tcof1 results in defects in middle ear postnatal development and conductive hearing loss.

  6. Results show that treacle is involved in ribosomal DNA gene transcription by interacting with upstream binding factor (UBF (Montrer UBTF Anticorps)).

  7. Data show that Tcof1 and treacle synthesis play an important role in the proliferation of neuroblastoma (Montrer ARHGEF16 Anticorps) cells.

  8. Analysis of RNA isolated from wild-type and Tcof1+/- heterozygous mice embryos from strains that exhibit a lethal phenotype showed significant reduction in 2'-O-methylation at nucleotide C463 of 18S rRNA

  9. A minimal promoter fragment from -253 to +43 bp (Montrer EIF4EBP1 Anticorps) directs constitutive expression in both cell types, and dual regulation of Tcof1 appears to be through differential repression of this minimal promoter.

  10. It has been hypothesized that mutations in Tcof1 disrupt ribosome biogenesis to a degree that is insufficient to meet the proliferative needs of the neuroepithelium and neural crest cells.

Human Treacher Collins-Franceschetti Syndrome 1 (TCOF1) interaction partners

  1. The analysis results showed that the Tcof1-related genes were enriched in various biological processes, including cell proliferation, apoptosis, cell cycle, differentiation, and migration.

  2. We report a clinical and extensive molecular study, including TCOF1, POLR1D (Montrer POLR1D Anticorps), POLR1C (Montrer POLR1C Anticorps), and EFTUD2 (Montrer EFTUD2 Anticorps) genes, in a series of 146 patients with TCS.

  3. Autosomal recessive POLR1D (Montrer POLR1D Anticorps) mutation with decrease of TCOF1 mRNA is responsible for Treacher Collins syndrome.

  4. findings identify TCOF1 as a DDR (Montrer DDR1 Anticorps) factor that could cooperate with ATM (Montrer ATM Anticorps) and NBS1 (Montrer NBN Anticorps) to suppress inappropriate rDNA transcription and maintain genomic integrity after DNA damage.

  5. we describe for the first time, two patients with MFD (Montrer SCYL1 Anticorps) and ID and for whom a deletion encompassing TCOF1 and CAMK2A (Montrer CAMK2A Anticorps) has been identified

  6. Mutations in TCOF1, POLR1C (Montrer POLR1C Anticorps) and POLR1D (Montrer POLR1D Anticorps) have all been implicated in causing TCS

  7. Treacle-mediated NBS1 (Montrer NBN Anticorps) recruitment into the nucleoli regulates rRNA silencing in trans in the presence of distant chromosome breaks.

  8. TCOF1 genetic mutation can be a cause of Treacher Collins syndrome in Chinese patients.

  9. Presents the case of a male with Treacher Collins syndrome with a heterozygous de novo frameshift mutation within the TCOF1 gene (c.790_791delAG,p.Ser264GlnfsX7), as well as findings from three other individuals from two families with the same mutation.

  10. 6 of 12 patients diagnosed with hemifacial microsomia exhibited a novel frameshift mutation c. 4127 ins (Montrer INS Anticorps) G in exon 24 in the TCOF1 gene.

TCOF1 profil antigène

Profil protéine

This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TCOF1

  • Treacher Collins-Franceschetti syndrome 1 (Tcof1) anticorps
  • Treacher Collins-Franceschetti syndrome 1 (TCOF1) anticorps
  • Treacher Collins-Franceschetti syndrome 1 (LOC100226238) anticorps
  • Treacher Collins-Franceschetti syndrome 1 (LOC100341764) anticorps
  • Treacher Collins Franceschetti syndrome 1, homolog (Tcof1) anticorps
  • AA408847 anticorps
  • AW209012 anticorps
  • MFD1 anticorps
  • TCOF1 anticorps
  • TCS1 anticorps
  • treacle anticorps

Protein level used designations for TCOF1

Treacher Collins Franceschetti syndrome 1, homolog , Treacher Collins-Franceschetti syndrome 1 homolog , treacle protein , tcof1 gene exons 14-15-16a-16b , tcof1 gene exons 7-13 , treacle , Treacher Collins-Franceschetti syndrome 1 , treacle protein-like , treacher Collins syndrome protein homolog , Treacher Collins syndrome protein , nucleolar trafficking phosphoprotein

291571 Rattus norvegicus
403592 Canis lupus familiaris
416276 Gallus gallus
471696 Pan troglodytes
513591 Bos taurus
664735 Macaca mulatta
100060348 Equus caballus
100226238 Taeniopygia guttata
100341764 Oryctolagus cuniculus
100435631 Pongo abelii
100471510 Ailuropoda melanoleuca
100591432 Nomascus leucogenys
21453 Mus musculus
6949 Homo sapiens
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