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TRIB2 encodes one of three members of the Tribbles family. De plus, nous expédions Tribbles Homolog 2 (Drosophila) Protéines (12) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 68 products:
Human Monoclonal TRIB2 Primary Antibody pour IHC (p), RNAi - ABIN565396
Wang, Zhang, Weng, Qiao, Ma, Xiao, Yu, Pan, Sun et al.: Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in ... dans The Journal of biological chemistry 2013
Show all 3 Pubmed References
Human Polyclonal TRIB2 Primary Antibody pour ICC, IF - ABIN4362344
Sung, Francis, Arnold, Holland, Ernst, Angyal, Kiss-Toth: Enhanced macrophage tribbles-1 expression in murine experimental atherosclerosis. dans Biology 2014
tissues expressing the highest levels of Xtrb2 were most markedly affected by morpholino knockdown, with perturbation of neural crest and eye development
O-GlcNAcylation of TRIB2 might be critical for diabetes-associated liver cancer.
Tumors from resistant patients expressed the lowest levels of TRIB2. Downregulation of TRIB2 contributes to platin-resistance.
our data show that excess p30 (Montrer CENPV Anticorps) cooperated with TRIB2 only in the presence of p42 (Montrer EPB42 Anticorps) to accelerate acute myeloid leukaemia (AML (Montrer RUNX1 Anticorps)), and the direct interaction and degradation of C/EBPa (Montrer CEBPA Anticorps) p42 (Montrer EPB42 Anticorps) is required for TRIB2-mediated AML (Montrer RUNX1 Anticorps).
miR (Montrer MLXIP Anticorps)-206 and miR (Montrer MLXIP Anticorps)-140, as tumor suppressors, induced lung adenocarcinoma cell death and inhibited cell proliferation by modifying oncogenic TRIB2 promoter activity through p-Smad3 (Montrer SMAD3 Anticorps).
Studied effect of TRIB2 SNP on the expression of genes involved in adaptive thermogenesis using messenger RNAs prepared from adipose tissues of Japanese adults. Of the five thermogenic genes, DIO2 (Montrer DIO2 Anticorps), CIDEA (Montrer CIDEA Anticorps), PPARGC1A (Montrer PPARGC1A Anticorps), and PRDM16 (Montrer PRDM16 Anticorps) showed significantly higher transcript levels in SAT of individuals with the AA genotype relative to those with the AT + TT genotype.
Data show that TRIB2-mediated degradation of CDC25C (Montrer CDC25C Anticorps) is associated with lysine-48-linked CDC25C (Montrer CDC25C Anticorps) polyubiquitination driven by the TRIB2 kinase-like domain.
High TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 (Montrer TAL1 Anticorps) complex in T-cell acute lymphoblastic leukemia.
Studies suggest that pseudo-kinase family of tribbles (Montrer TRIB1 Anticorps) (TRIB) proteins TRIB1 (Montrer TRIB1 Anticorps), TRIB2 and TRIB3 (Montrer TRIB3 Anticorps) play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis.
Studies suggest that pseudo-kinase family of tribbles (Montrer TRIB1 Anticorps) (TRIB) proteins TRIB1 (Montrer TRIB1 Anticorps), TRIB2 and TRIB3 (Montrer TRIB3 Anticorps) were involved in the pathogenesis of inflammation.
Studies suggest that tribbles homolog 2 (Drosophila) protein (TRIB2) as a meaningful biomarker to both diagnose and stage melanoma.
The absence of a change in hypocretin (Montrer OX Anticorps) cell populations suggested that factors other than anti-TRIB2 antibody play a part in the loss of hypocretin (Montrer OX Anticorps) neurons in narcolepsy. The increased anti-TRIB2 antibody after the destruction of hypocretin (Montrer OX Anticorps) neurons suggest that anti-TRIB2 antibody in narcolepsy patients is the consequence rather than the inciting cause of hypocretin (Montrer OX Anticorps) cell destruction.
These data indicate that Trib2 has a complex role in the pathogenesis of Notch (Montrer NOTCH1 Anticorps)-driven T-ALL, which may vary between different T-ALL subtypes.
TRIB1 (Montrer TRIB1 Anticorps) and TRIB3 (Montrer TRIB3 Anticorps) are more strongly expressed than TRIB2 in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.
we identify the contribution of dysregulated C/EBPalpha (Montrer CEBPA Anticorps) and E2F1 (Montrer E2F1 Anticorps) to elevated Trib2 expression and leukemic cell survival
Trib2 transduced hematopoietic stem cells developed acute myeloid leukemia (Montrer BCL11A Anticorps).
Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients.
Data identify Tribbles homolog 2 as an oncogene (Montrer RAB1A Anticorps) that induces acute myelogenous leukemia through a mechanism involving inactivation of C/EBPalpha (Montrer CEBPA Anticorps).
describe suppression of adipocyte differentiation by TRBs Trib1 (Montrer TRIB1 Anticorps), Trib2, Trib3 (Montrer TRIB3 Anticorps)
Mice reconstituted with HSC (Montrer FUT1 Anticorps) cotransduced with HoxA9 (Montrer HOXA9 Anticorps) and Trib2 had accelerated onset of AML (Montrer RUNX1 Anticorps) compared to either gene alone
Linkage of Meis1 (Montrer MEIS1 Anticorps) leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3 (Montrer CCL3 Anticorps).
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
tribbles homolog 2 (Drosophila)
, tribbles homolog 2-like
, tribbles homolog 2
, serine/threonine protein kinase
, tribbles-like protein 2