CD40 Ligand anticorps

N° du produit ABIN1105903

Détail du produit anti-CD40 Ligand anticorps

Antigène: CD40 Ligand (CD40LG)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD40 Ligand est non-conjugé

Application: Flow Cytometry (FACS)

Specificité: This antibody reacts with CD154 antigen.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein A agarose

Immunogène: Human CD154 transfected 300-19 cell (mouse pre-B cell line)

Clone: 5F3

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Prepare a stock solution by dissolving the lyophilized antibody in 100 μL of distilled water. After reconstitution, the IgG concentration should be 1 mg/mL.

Buffer: PBS ( pH 7.2) without preservatives, 1 % sucrose

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store (in aliquots) at -20 °C.

Détails sur CD40 Ligand

Antigène: CD40 Ligand (CD40LG)

Autre désignation: CD154 / CD40L (CD40LG Produits)

Synonymes: anticorps CD154, anticorps cd40l, anticorps CD40L, anticorps HIGM1, anticorps IGM, anticorps IMD3, anticorps T-BAM, anticorps TNFSF5, anticorps TRAP, anticorps gp39, anticorps hCD40L, anticorps CD40-L, anticorps Cd40l, anticorps Ly-62, anticorps Ly62, anticorps Tnfsf5, anticorps CD40 ligand, anticorps TNF superfamily member 5, anticorps CD40LG, anticorps cd40l, anticorps Cd40lg

Sujet: The human CD154 (CD40-ligand) is a 39 kDa type II membrane glycoprotein predominantly expressed on CD4+ T cells, but also on a small proportion of CD8+ cells and NK cells. It belongs to the tumor necrosis factor (TNF) family, while its counter receptor on B cells, CD40, is a member of the TNF receptor/nerve growth factor (NGF) receptor family. Interactions between CD40 on B cells and its ligand on activated T cells results in B cell activation, proliferation, aggregation, and immunoglobulin isotype switching. A defect in the gene encoding CD154 is responsible for X-linked immunoglobulin deficiency with normal or elevated IgM (X-linked hyper IgM). These patients produce IgM but fail to produce downstream Ig isotypes, suggesting that interaction between CD40 on B cells and its ligand on activated T cells plays a critical role in Ig heavy chain switch recombination. The expression of CD154 on activated T cells is tightly regulated. B cells down-regulate the expression of functional CD154 in activated T cells through the inhibition of CD154 mRNA expression and the release of soluble CD40 that binds CD154.Synonyms: CD40 ligand, CD40-L, CD40LG, GP39, T-cell antigen Gp39, TNF-related activation protein, TNFSF5, TRAP, Tumor necrosis factor ligand superfamily member 5

ID gène: 959

NCBI Accession: NP_000065

UniProt: P29965

Pathways: Signalisation NF-kappaB, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints