TIS11B is a member of the tristetraprolin family. Tristetraprolin (TTP), or TIS11, is a zinc-binding protein encoded by the immediate-early response gene, Zfp-36. TIS11B, a relative of TTP, localizes to the nucleus and may function as a transcription factor involved in regulating the growth factor response. It is an evolutionarily conserved protein containing two C3H1-type zinc fingers and a repeating cys-his motif. TIS11B is an mRNA binding protein and is known to interact with the 3â€™-untranslated region of VEGF mRNA, thereby decreasing its stability. This suggests that TIS11B is a potential target in antiangiogenic therapy. In addition, TIS11B may also be an important regulator of myogenesis, as its expression is upregulated during murine myoblast differentiation.
Synonyms: Berg36, BRF1, Butyrate response factor 1, C3H1 type-like 1, cMG1, Early response factor Berg36, EGF response factor 1, EGF-response factor 1, ERF 1, ERF-1, ERF1, Protein TIS11B, RNF162B, TIS11B, TISB_HUMAN, ZFP36L1, Zinc finger protein 36, Zinc finger protein 36 C3H type like 1, zinc finger protein C3H type 36 like 1.