AGT anticorps (N-Term)

N° du produit ABIN1882205

Détail du produit anti-AGT anticorps

Antigène: AGT (Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT))

Épitope: AA 37-65, N-Term

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp AGT est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This AGT antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human AGT.

Clone: 656CT5-8-4

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:100~1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-AGT (ABIN1882205)

Desong Liu, Fang Lu, Songhui Zhai, Liu Wei, Shi Ma, Xiuying Chen, Liqun Dong, Yannan Guo, Jin Wu, Zheng Wang: "Renin-angiotensin system gene polymorphisms in children with Henoch-Schönlein purpura in West China." dans: Journal of the renin-angiotensin-aldosterone system : JRAAS, Vol. 11, Issue 4, pp. 248-55, (2010) (PubMed).

Kieć-Wilk, Olszanecka, Mikołajczyk, Kawecka-Jaszcz et al.: "[Role of the M235T (c.704c>T) polymorphism of angiotensynogen gene as well as A724A (c.2171G>A) polymorphism of SERCA2a gene in ethiopathogenesis of left ventricular hypertrophy in essential..." dans: Przegla̧d lekarski, Vol. 67, Issue 3, pp. 151-6, (2010) (PubMed).

Procopciuc, Sitar-Tăut, Pop, Sitar-Tăut, Olteanu, Zdrenghea: "Renin angiotensin system polymorphisms in patients with metabolic syndrome (MetS)." dans: European journal of internal medicine, Vol. 21, Issue 5, pp. 414-8, (2010) (PubMed).

Détails sur AGT

Antigène: AGT (Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT))

Autre désignation: AGT (AGT Produits)

Synonymes: anticorps ANHU, anticorps SERPINA8, anticorps AI265500, anticorps AngI, anticorps AngII, anticorps Aogen, anticorps Serpina8, anticorps ANRT, anticorps Ang, anticorps PAT, anticorps wu:fb62f06, anticorps wu:fj87b02, anticorps zgc:111892, anticorps AGT, anticorps angt, anticorps ANGT, anticorps angiotensinogen, anticorps angiotensinogen (serpin peptidase inhibitor, clade A, member 8), anticorps AGT, anticorps Agt, anticorps agt

Sujet: The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Poids moléculaire: 53154

NCBI Accession: NP_000020

UniProt: P01019

Pathways: Signalistation JAK/STAT, ACE Inhibitor Pathway, EGFR Signaling Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Feeding Behaviour, Monocarboxylic Acid Catabolic Process, Dicarboxylic Acid Transport, Positive Regulation of Response to DNA Damage Stimulus, Regulation of long-term Neuronal Synaptic Plasticity