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Calnexin anticorps (C-Term)

CANX Reactivité: Chien WB, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN361827
  • Antigène Voir toutes Calnexin (CANX) Anticorps
    Calnexin (CANX)
    Épitope
    • 48
    • 17
    • 14
    • 6
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 119
    • 75
    • 74
    • 49
    • 34
    • 31
    • 31
    • 29
    • 29
    • 26
    • 25
    • 25
    • 22
    • 21
    • 20
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Chien
    Hôte
    • 116
    • 25
    • 7
    Lapin
    Clonalité
    • 113
    • 36
    Polyclonal
    Conjugué
    • 72
    • 8
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Calnexin est non-conjugé
    Application
    • 124
    • 80
    • 56
    • 56
    • 41
    • 27
    • 27
    • 26
    • 21
    • 14
    • 13
    • 9
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Detects the C-terminal domain of Calnexin ~90 kDa. Weak detection in Chicken, Drosophila, and Xenopus tissues
     Réactivité croisée
    Poulet, Boeuf (Vache), Chien, Drosophila melanogaster, Cobaye, Hamster, Humain, Singe, Souris, Porc, Caille, Lapin, Rat, Mouton, Xenopus laevis
    Purification
    Peptide Affinity Purified
    Immunogène
    Dog calnexin C-terminal synthetic peptide conjugated to KLH. Identical to human, mouse and rat calnexin sequences over these residues.
    Top Product
    Discover our top product CANX Anticorps primaire
  • Indications d'application
    • WB (1:1000)
    • IHC (1:100)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    A 1:1000 dilution of ABIN361826 was sufficient for detection of Calnexin in 10 μg of HeLa cell lysate by ECL immunoblot analysis.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C
  • Quintas, Pérez-Núñez, Sánchez, Nogal, Hentze, Castelló, Revilla: "Characterization of the African Swine Fever Virus Decapping Enzyme during Infection." dans: Journal of virology, Vol. 91, Issue 24, (2017) (PubMed).

    Hernández-Tiedra, Fabriàs, Dávila, Salanueva, Casas, Montes, Antón, García-Taboada, Salazar-Roa, Lorente, Nylandsted, Armstrong, López-Valero, McKee, Serrano-Puebla, García-López, González-Martínez et al.: "Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. ..." dans: Autophagy, Vol. 12, Issue 11, pp. 2213-2229, (2017) (PubMed).

    Gordo-Gilart, Hierro, Andueza, Muñoz-Bartolo, López, Díaz, Jara, Álvarez: "Heterozygous ABCB4 mutations in children with cholestatic liver disease." dans: Liver international : official journal of the International Association for the Study of the Liver, (2015) (PubMed).

    Gordo-Gilart, Andueza, Hierro, Martínez-Fernández, DAgostino, Jara, Alvarez: "Functional analysis of ABCB4 mutations relates clinical outcomes of progressive familial intrahepatic cholestasis type 3 to the degree of MDR3 floppase activity." dans: Gut, Vol. 64, Issue 1, pp. 147-55, (2014) (PubMed).

    Williams, Tulke, Ilegems, Berggren, Broberger: "Expression of nucleobindin 1 (NUCB1) in pancreatic islets and other endocrine tissues." dans: Cell and tissue research, Vol. 358, Issue 2, pp. 331-42, (2014) (PubMed).

    Martín-Acebes, Merino-Ramos, Blázquez, Casas, Escribano-Romero, Sobrino, Saiz: "The composition of West Nile virus lipid envelope unveils a role of sphingolipid metabolism in flavivirus biogenesis." dans: Journal of virology, Vol. 88, Issue 20, pp. 12041-54, (2014) (PubMed).

  • Antigène
    Calnexin (CANX)
    Autre désignation
    Calnexin (CANX Produits)
    Synonymes
    anticorps CNX, anticorps IP90, anticorps P90, anticorps 1110069N15Rik, anticorps AI988026, anticorps Cnx, anticorps D11Ertd153e, anticorps canx, anticorps clgn, anticorps clnx, anticorps cnx, anticorps PP90, anticorps zgc:63524, anticorps wu:fe06b12, anticorps CANX, anticorps calnexin, anticorps CalNeXin, anticorps calnexin L homeolog, anticorps CANX, anticorps Canx, anticorps cnx-1, anticorps canx.L, anticorps canx, anticorps LOC100283947
    Sujet
    Calnexin, an abundant ~90 kDa integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90 (1). It consists of a large 50 kDa N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail (2, 3). Unlike its ER counterparts which have a KDEL sequence on their C-terminus to ensure ER retention (4), calnexin has positively charged cytosolic residues that do the same thing (3). Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multi-subunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their mono-glycosylated glycans (5, 6). Calnexin has also been shown to associate with the major histocompatibility complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin (7).
    ID gène
    403908
    NCBI Accession
    NP_001003232
    UniProt
    P24643
    Pathways
    Signalisation MAPK, Thyroid Hormone Synthesis
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