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LC3B anticorps (pThr12)

MAP1LC3B Reactivité: Humain DB Hôte: Lapin Polyclonal RB12679 unconjugated
N° du produit ABIN389913
  • Antigène Voir toutes LC3B (MAP1LC3B) Anticorps
    LC3B (MAP1LC3B) (Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B))
    Épitope
    • 23
    • 15
    • 15
    • 12
    • 9
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr12
    Reactivité
    • 134
    • 51
    • 36
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 123
    • 14
    • 7
    Lapin
    Clonalité
    • 129
    • 16
    Polyclonal
    Conjugué
    • 76
    • 14
    • 13
    • 10
    • 10
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp LC3B est non-conjugé
    Application
    • 89
    • 55
    • 52
    • 28
    • 24
    • 14
    • 13
    • 10
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    Dot Blot (DB)
    Homologie
    B
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This LC3B Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T12 of human LC3B.
    Clone
    RB12679
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MAP1LC3B Anticorps primaire
  • Indications d'application
    DB: 1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Mitroulis, Kourtzelis, Kambas, Rafail, Chrysanthopoulou, Speletas, Ritis: "Regulation of the autophagic machinery in human neutrophils." dans: European journal of immunology, Vol. 40, Issue 5, pp. 1461-72, (2010) (PubMed).

  • Antigène
    LC3B (MAP1LC3B) (Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B))
    Autre désignation
    LC3B (MAP1LC3B Produits)
    Synonymes
    anticorps ATG8F, anticorps LC3B, anticorps MAP1A/1BLC3, anticorps MAP1LC3B-a, anticorps Map1lc3, anticorps Mpl3, anticorps zbs559, anticorps 1010001C15Rik, anticorps Atg8, anticorps LC3b, anticorps zgc:56434, anticorps wu:fb60g11, anticorps map1lc3b, anticorps MGC76283, anticorps MAP1LC3B, anticorps microtubule associated protein 1 light chain 3 beta, anticorps microtubule-associated protein 1 light chain 3 beta, anticorps microtubule associated protein 1 light chain 3 beta L homeolog, anticorps MAP1LC3B, anticorps Map1lc3b, anticorps map1lc3b, anticorps map1lc3b.L
    Sujet
    MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3b is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole).
    Poids moléculaire
    14688
    ID gène
    81631
    NCBI Accession
    NP_073729
    UniProt
    Q9GZQ8
    Pathways
    Autophagy
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