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Carabin anticorps (C-Term)

TBC1D10C Reactivité: Humain, Souris WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499529
  • Antigène Voir toutes Carabin (TBC1D10C) Anticorps
    Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))
    Épitope
    • 5
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris
    Hôte
    • 8
    • 1
    Lapin
    Clonalité
    • 9
    Polyclonal
    Conjugué
    • 9
    Cet anticorp Carabin est non-conjugé
    Application
    • 9
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts to Carabin.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    Carabin antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Carabin.
    Isotype
    IgG
    Top Product
    Discover our top product TBC1D10C Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: Carabin antibody can be used for detection of Carabin at 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))
    Autre désignation
    Carabin (TBC1D10C Produits)
    Synonymes
    anticorps CARABIN, anticorps EPI64C, anticorps 1810062O14Rik, anticorps AI428527, anticorps RGD1311490, anticorps TBC1 domain family member 10C, anticorps TBC1 domain family, member 10c, anticorps TBC1 domain family, member 10C, anticorps TBC1D10C, anticorps Tbc1d10c
    Sujet
    Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.Synonyms: TBC1 domain family member 10C, TBC1D10C
    ID gène
    374403
    NCBI Accession
    NP_940919
    UniProt
    Q8IV04
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