TMPRSS6 anticorps (N-Term)

N° du produit ABIN503447

Détail du produit anti-TMPRSS6 anticorps

Antigène: TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMPRSS6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: LLWYFLGYKA EVMVSQVYSG SLRVLNRHFS QDLTRRESSA FRSETAKAQK

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against TMPRSS6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human TMPRSS6

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 811 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TMPRSS6

Antigène: TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))

Autre désignation: TMPRSS6 (TMPRSS6 Produits)

Synonymes: anticorps IRIDA, anticorps 1300008A22Rik, anticorps transmembrane protease, serine 6, anticorps transmembrane serine protease 6, anticorps Tmprss6, anticorps TMPRSS6

Sujet: TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter.The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
Alias Symbols: IRIDA
Protein Interaction Partner: LAMA1, FN1, COL1A1,
Protein Size: 811

Poids moléculaire: 90 kDa

ID gène: 164656

NCBI Accession: NM_153609, NP_705837

UniProt: Q8IU80

Pathways: Transition Metal Ion Homeostasis