RASA1 anticorps (C-Term)

N° du produit ABIN656874

Détail du produit anti-RASA1 anticorps

Antigène: RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))

Épitope: AA 966-993, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RASA1 est non-conjugé

Application: Western Blotting (WB)

Homologie: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This RASA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 966-993 amino acids from the C-terminal region of human RASA1.

Clone: RB31772

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: RASA1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Date de péremption: 6 months

Détails sur RASA1

Antigène: RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))

Autre désignation: RASA1 (RASA1 Produits)

Synonymes: anticorps CG9209, anticorps D-RasGAP, anticorps Dmel\\CG9209, anticorps RAS-GAP, anticorps RasGAP, anticorps RasGap, anticorps rasGap, anticorps CM-AVM, anticorps CMAVM, anticorps GAP, anticorps PKWS, anticorps RASA, anticorps RASGAP, anticorps p120GAP, anticorps p120RASGAP, anticorps GAPX, anticorps Rasa, anticorps Gap, anticorps vacuolar peduncle, anticorps RAS p21 protein activator 1, anticorps vap, anticorps RASA1, anticorps Rasa1

Sujet: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.

Poids moléculaire: 116403

ID gène: 5921

NCBI Accession: NP_002881, NP_072179

UniProt: P20936

Pathways: Regulation of Actin Filament Polymerization, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals