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CD16 anticorps (PE)

CD16 Reactivité: Humain, Non-Human Primate FACS Hôte: Souris Monoclonal LNK16 PE
N° du produit ABIN93990
  • Antigène Voir toutes CD16 Anticorps
    CD16
    Reactivité
    • 143
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    • 8
    • 8
    • 4
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    • 2
    • 2
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    Humain, Non-Human Primate
    Hôte
    • 127
    • 29
    • 14
    • 1
    Souris
    Clonalité
    • 143
    • 26
    • 1
    Monoclonal
    Conjugué
    • 59
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    • 3
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    • 3
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    • 2
    • 2
    • 2
    • 2
    • 2
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    • 1
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    • 1
    • 1
    • 1
    • 1
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    • 1
    • 1
    • 1
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    Cet anticorp CD16 est conjugé à/à la PE
    Application
    • 136
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    Flow Cytometry (FACS)
    Specificité
    The antibody LNK16 reacts with an extracellular epitope of CD16, a low affinity receptor for aggregated IgG (FcgammaRIII antigen). CD16 exists in two different isoforms: CD16a (FcgammaRIIIA, 50-65 kDa, expressed on NK-cells, monocytes and macrophages) and CD16b (FcgammaRIIIB, 48 kDa, mainly expressed on neutrophils).
    Réactivité croisée (Details)
    Human, Non-Human Primates
    Purification
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Normal human peripheral blood granulocytes
    Clone
    LNK16
    Isotype
    IgG1
    Top Product
    Discover our top product CD16 Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Hovden, Karlsen, Jonsson, Aarstad, Appel: "Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses." dans: BMC immunology, Vol. 12, pp. 2, (2011) (PubMed).

    Boyle: "Human macrophages kill human mesangial cells by Fas-L-induced apoptosis when triggered by antibody via CD16." dans: Clinical and experimental immunology, Vol. 137, Issue 3, pp. 529-37, (2004) (PubMed).

    Mathison, Befus, Davison, Woodman: "Modulation of neutrophil function by the tripeptide feG." dans: BMC immunology, Vol. 4, pp. 3, (2003) (PubMed).

    Tamm, Schmidt: "The binding epitopes of human CD16 (Fc gamma RIII) monoclonal antibodies. Implications for ligand binding." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 157, Issue 4, pp. 1576-81, (1996) (PubMed).

  • Antigène
    CD16
    Autre désignation
    CD16 (CD16 Produits)
    Synonymes
    anticorps Fcgr3, anticorps Fcgr3a, anticorps CD16, anticorps FCGR3, anticorps FCGR3@, anticorps CD16b, anticorps FCG3, anticorps FCR-10, anticorps FCRIII, anticorps FCRIIIb, anticorps FcRIII, anticorps Fc fragment of IgG, low affinity IIa, receptor, anticorps Fc fragment of IgG, low affinity IIIa, receptor (CD16a), anticorps Fc fragment of IgG receptor IIIb, anticorps Fc fragment of IgG receptor IIIa, anticorps Fc receptor, IgG, low affinity III, anticorps Fc-gamma RIII, anticorps Fcgr2a, anticorps FCGR3A, anticorps FCGR3B, anticorps Fcgr3, anticorps FCGR3
    Sujet
    CD16 (FcgammaRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgammaRIII is expressed in two forms –, FcgammaRIII-A and -B. FcgammaRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgammaRIII-A is associated, moreover, with FcepsilonRI-beta subunit. Besides IgG, FcgammaRIII-A can be triggered also by oligomeric IgE. FcgammaRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.,FcgammaRIII, IGFR3, FCRIII
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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